Localization of metabotropic glutamate receptors in the outer plexiform layer of the goldfish retina

Christina Joselevitch; Jan Klooster; Maarten Kamermans

doi:https://doi.org/10.1007/s00441-007-0496-1

Localization of metabotropic glutamate receptors in the outer plexiform layer of the goldfish retina

Christina Joselevitch, Jan Klooster, Maarten Kamermans

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

We studied the localization of metabotropic glutamate receptors (mGluRs) in the goldfish outer plexiform layer by light-and electron-microscopical immunohistochemistry. The mGluR1alpha antibody labeled putative ON-type bipolar cell dendrites and horizontal cell processes in both rod spherules and cone triads. Immunolabeling for mGluR2/3 was absent in the rod synaptic complex but was found at horizontal cell dendrites directly opposing the cone synaptic ribbon. The mGluR5 antibody labeled Müller cell processes wrapping rod terminals and horizontal cell somata. The mGluR7 antibody labeled mainly horizontal cell dendrites invaginating rods and cones and some putative bipolar cell dendrites in the cone synaptic complex. The finding of abundant expression of various mGluRs in bipolar and horizontal cell dendrites suggests multiple sites of glutamatergic modulation in the outer retina

Original language	English
Pages (from-to)	389-403
Journal	Cell and Tissue Research
Volume	330
Issue number	3
DOIs	https://doi.org/10.1007/s00441-007-0496-1
Publication status	Published - 2007

Access to Document

https://doi.org/10.1007/s00441-007-0496-1

Cite this

@article{9bf190951ef3432f80260c087bdd0d53,

title = "Localization of metabotropic glutamate receptors in the outer plexiform layer of the goldfish retina",

abstract = "We studied the localization of metabotropic glutamate receptors (mGluRs) in the goldfish outer plexiform layer by light-and electron-microscopical immunohistochemistry. The mGluR1alpha antibody labeled putative ON-type bipolar cell dendrites and horizontal cell processes in both rod spherules and cone triads. Immunolabeling for mGluR2/3 was absent in the rod synaptic complex but was found at horizontal cell dendrites directly opposing the cone synaptic ribbon. The mGluR5 antibody labeled M{\"u}ller cell processes wrapping rod terminals and horizontal cell somata. The mGluR7 antibody labeled mainly horizontal cell dendrites invaginating rods and cones and some putative bipolar cell dendrites in the cone synaptic complex. The finding of abundant expression of various mGluRs in bipolar and horizontal cell dendrites suggests multiple sites of glutamatergic modulation in the outer retina",

author = "Christina Joselevitch and Jan Klooster and Maarten Kamermans",

year = "2007",

doi = "https://doi.org/10.1007/s00441-007-0496-1",

language = "English",

volume = "330",

pages = "389--403",

journal = "Cell and Tissue Research",

issn = "0302-766X",

publisher = "Springer Verlag",

number = "3",

}

TY - JOUR

T1 - Localization of metabotropic glutamate receptors in the outer plexiform layer of the goldfish retina

AU - Joselevitch, Christina

AU - Klooster, Jan

AU - Kamermans, Maarten

PY - 2007

Y1 - 2007

N2 - We studied the localization of metabotropic glutamate receptors (mGluRs) in the goldfish outer plexiform layer by light-and electron-microscopical immunohistochemistry. The mGluR1alpha antibody labeled putative ON-type bipolar cell dendrites and horizontal cell processes in both rod spherules and cone triads. Immunolabeling for mGluR2/3 was absent in the rod synaptic complex but was found at horizontal cell dendrites directly opposing the cone synaptic ribbon. The mGluR5 antibody labeled Müller cell processes wrapping rod terminals and horizontal cell somata. The mGluR7 antibody labeled mainly horizontal cell dendrites invaginating rods and cones and some putative bipolar cell dendrites in the cone synaptic complex. The finding of abundant expression of various mGluRs in bipolar and horizontal cell dendrites suggests multiple sites of glutamatergic modulation in the outer retina

AB - We studied the localization of metabotropic glutamate receptors (mGluRs) in the goldfish outer plexiform layer by light-and electron-microscopical immunohistochemistry. The mGluR1alpha antibody labeled putative ON-type bipolar cell dendrites and horizontal cell processes in both rod spherules and cone triads. Immunolabeling for mGluR2/3 was absent in the rod synaptic complex but was found at horizontal cell dendrites directly opposing the cone synaptic ribbon. The mGluR5 antibody labeled Müller cell processes wrapping rod terminals and horizontal cell somata. The mGluR7 antibody labeled mainly horizontal cell dendrites invaginating rods and cones and some putative bipolar cell dendrites in the cone synaptic complex. The finding of abundant expression of various mGluRs in bipolar and horizontal cell dendrites suggests multiple sites of glutamatergic modulation in the outer retina

U2 - https://doi.org/10.1007/s00441-007-0496-1

DO - https://doi.org/10.1007/s00441-007-0496-1

M3 - Article

C2 - 17906878

SN - 0302-766X

VL - 330

SP - 389

EP - 403

JO - Cell and Tissue Research

JF - Cell and Tissue Research

IS - 3

ER -