TY - JOUR
T1 - Locally advanced pancreatic cancer: A review of local ablative therapies
AU - Ruarus, Alette
AU - Vroomen, Laurien
AU - Puijk, Robbert
AU - Scheffer, Hester
AU - Meijerink, Martijn
PY - 2018
Y1 - 2018
N2 - Pancreatic cancer is typically characterized by its aggressive tumor growth and dismal prognosis. Approximately 30% of patients with pancreatic cancer present with locally advanced disease, broadly defined as having a tumor-to-artery interface >180°, having an unreconstructable portal vein or superior mesenteric vein and no signs of metastatic disease. These patients are currently designated to palliative systemic chemotherapy, though median overall survival remains poor (approximately 11 months). Therefore, several innovative local therapies have been investigated as new treatment options for locally advanced pancreatic cancer (LAPC). This article provides an overview of available data with regard to morbidity and oncological outcome of novel local therapies for LAPC.
AB - Pancreatic cancer is typically characterized by its aggressive tumor growth and dismal prognosis. Approximately 30% of patients with pancreatic cancer present with locally advanced disease, broadly defined as having a tumor-to-artery interface >180°, having an unreconstructable portal vein or superior mesenteric vein and no signs of metastatic disease. These patients are currently designated to palliative systemic chemotherapy, though median overall survival remains poor (approximately 11 months). Therefore, several innovative local therapies have been investigated as new treatment options for locally advanced pancreatic cancer (LAPC). This article provides an overview of available data with regard to morbidity and oncological outcome of novel local therapies for LAPC.
KW - Local ablative therapies
KW - Locally advanced pancreatic cancer (LAPC)
KW - Pancreatic cancer
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85040835302&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29320420
U2 - https://doi.org/10.3390/cancers10010016
DO - https://doi.org/10.3390/cancers10010016
M3 - Review article
C2 - 29320420
SN - 2072-6694
VL - 10
JO - Cancers
JF - Cancers
IS - 1
M1 - 16
ER -