Loci at chromosomes 13, 19 and 20 influence age at natural menopause

L. Stolk; G. Zhai; J.B.J. van Meurs; M.M.P.J. Verbiest; J.A. Visser; K. Estrada; F. Rivadeneira; F.M. Williams; L. Cherkas; P. Deloukas; N. Soranzo; J.J. de Keyzer; V.J.M. Pop; P.T.A.M. Lips; C.E.I. Lebrun; Y.T. van der Schouw; D.E. Grobbee; J. Witteman; A. Hofman; H.A.P. Pols; J.S.E. Laven; T.D. Spector; A.G. Uitterlinden

doi:https://doi.org/10.1038/ng.387

Loci at chromosomes 13, 19 and 20 influence age at natural menopause

L. Stolk, G. Zhai, J.B.J. van Meurs, M.M.P.J. Verbiest, J.A. Visser, K. Estrada, F. Rivadeneira, F.M. Williams, L. Cherkas, P. Deloukas, N. Soranzo, J.J. de Keyzer, V.J.M. Pop, P.T.A.M. Lips, C.E.I. Lebrun, Y.T. van der Schouw, D.E. Grobbee, J. Witteman, A. Hofman, H.A.P. PolsJ.S.E. Laven, T.D. Spector, A.G. Uitterlinden

Internal Medicine (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

140 Citations (Scopus)

Abstract

We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10 11), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10 11) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10 8). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

Original language	English
Pages (from-to)	645-647
Journal	Nature Genetics
Volume	41
Issue number	6
DOIs	https://doi.org/10.1038/ng.387
Publication status	Published - 2009

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Cite this

Stolk, L., Zhai, G., van Meurs, J. B. J., Verbiest, M. M. P. J., Visser, J. A., Estrada, K., Rivadeneira, F., Williams, F. M., Cherkas, L., Deloukas, P., Soranzo, N., de Keyzer, J. J., Pop, V. J. M., Lips, P. T. A. M., Lebrun, C. E. I., van der Schouw, Y. T., Grobbee, D. E., Witteman, J., Hofman, A., ... Uitterlinden, A. G. (2009). Loci at chromosomes 13, 19 and 20 influence age at natural menopause. Nature Genetics, 41(6), 645-647. https://doi.org/10.1038/ng.387

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title = "Loci at chromosomes 13, 19 and 20 influence age at natural menopause",

abstract = "We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10 11), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10 11) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10 8). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.",

author = "L. Stolk and G. Zhai and {van Meurs}, J.B.J. and M.M.P.J. Verbiest and J.A. Visser and K. Estrada and F. Rivadeneira and F.M. Williams and L. Cherkas and P. Deloukas and N. Soranzo and {de Keyzer}, J.J. and V.J.M. Pop and P.T.A.M. Lips and C.E.I. Lebrun and {van der Schouw}, Y.T. and D.E. Grobbee and J. Witteman and A. Hofman and H.A.P. Pols and J.S.E. Laven and T.D. Spector and A.G. Uitterlinden",

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Stolk, L, Zhai, G, van Meurs, JBJ, Verbiest, MMPJ, Visser, JA, Estrada, K, Rivadeneira, F, Williams, FM, Cherkas, L, Deloukas, P, Soranzo, N, de Keyzer, JJ, Pop, VJM, Lips, PTAM, Lebrun, CEI, van der Schouw, YT, Grobbee, DE, Witteman, J, Hofman, A, Pols, HAP, Laven, JSE, Spector, TD & Uitterlinden, AG 2009, 'Loci at chromosomes 13, 19 and 20 influence age at natural menopause', Nature Genetics, vol. 41, no. 6, pp. 645-647. https://doi.org/10.1038/ng.387

TY - JOUR

T1 - Loci at chromosomes 13, 19 and 20 influence age at natural menopause

AU - Stolk, L.

AU - Zhai, G.

AU - van Meurs, J.B.J.

AU - Verbiest, M.M.P.J.

AU - Visser, J.A.

AU - Estrada, K.

AU - Rivadeneira, F.

AU - Williams, F.M.

AU - Cherkas, L.

AU - Deloukas, P.

AU - Soranzo, N.

AU - de Keyzer, J.J.

AU - Pop, V.J.M.

AU - Lips, P.T.A.M.

AU - Lebrun, C.E.I.

AU - van der Schouw, Y.T.

AU - Grobbee, D.E.

AU - Witteman, J.

AU - Hofman, A.

AU - Pols, H.A.P.

AU - Laven, J.S.E.

AU - Spector, T.D.

AU - Uitterlinden, A.G.

PY - 2009

Y1 - 2009

N2 - We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10 11), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10 11) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10 8). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

AB - We conducted a genome-wide association study for age at natural menopause in 2,979 European women and identified six SNPs in three loci associated with age at natural menopause: chromosome 19q13.4 (rs1172822; -0.4 year per T allele (39%); P = 6.3 × 10 11), chromosome 20p12.3 (rs236114; +0.5 year per A allele (21%); P = 9.7 × 10 11) and chromosome 13q34 (rs7333181; +0.5 year per A allele (12%); P = 2.5 × 10 8). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease.

U2 - https://doi.org/10.1038/ng.387

DO - https://doi.org/10.1038/ng.387

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