Locoregionale radiotherapie na mastectomie en chemotherapie wegens mammacarcinoom: verlengde overleving en betere lokale tumorcontrole

H. Struikmans; G. van Tienhoven; J. J. Jobsen; J. J. Jager; J. H. Borger; L. J. Scheijmans

Locoregionale radiotherapie na mastectomie en chemotherapie wegens mammacarcinoom: verlengde overleving en betere lokale tumorcontrole

H. Struikmans, G. van Tienhoven, J. J. Jobsen, J. J. Jager, J. H. Borger, L. J. Scheijmans

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Abstract

In two recent randomized clinical trials from Denmark and Canada the usefulness of radiotherapy was evaluated in premenopausal patients with breast cancer who had been operated and in whom the findings indicated a poor prognosis. Over 2000 patients participated. After follow-up periods of 10 and 15 years, respectively, addition of locoregional therapy to mastectomy and chemotherapy with cyclophosphamide, methotrexate and fluorouracil (CMF) was found to result in better locoregional control and a better disease-free survival. These studies also demonstrated, for the first time, that the overall survival was increased after postoperative radiotherapy. In view of these findings, the indication for postoperative locoregional radiotherapy in breast cancer in the Netherlands should be reconsidered

Original language	Dutch
Pages (from-to)	71-73
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	143
Issue number	2
Publication status	Published - 1999

Cite this

@article{d06a19befca649b186e6fa6e16bfe2c0,

title = "Locoregionale radiotherapie na mastectomie en chemotherapie wegens mammacarcinoom: verlengde overleving en betere lokale tumorcontrole",

abstract = "In two recent randomized clinical trials from Denmark and Canada the usefulness of radiotherapy was evaluated in premenopausal patients with breast cancer who had been operated and in whom the findings indicated a poor prognosis. Over 2000 patients participated. After follow-up periods of 10 and 15 years, respectively, addition of locoregional therapy to mastectomy and chemotherapy with cyclophosphamide, methotrexate and fluorouracil (CMF) was found to result in better locoregional control and a better disease-free survival. These studies also demonstrated, for the first time, that the overall survival was increased after postoperative radiotherapy. In view of these findings, the indication for postoperative locoregional radiotherapy in breast cancer in the Netherlands should be reconsidered",

author = "H. Struikmans and {van Tienhoven}, G. and Jobsen, {J. J.} and Jager, {J. J.} and Borger, {J. H.} and Scheijmans, {L. J.}",

year = "1999",

language = "Dutch",

volume = "143",

pages = "71--73",

journal = "Nederlands Tijdschrift voor Geneeskunde",

issn = "0028-2162",

publisher = "Vereniging Nederlands Tijdschrift voor Geneeskunde",

number = "2",

}

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T1 - Locoregionale radiotherapie na mastectomie en chemotherapie wegens mammacarcinoom: verlengde overleving en betere lokale tumorcontrole

AU - Struikmans, H.

AU - van Tienhoven, G.

AU - Jobsen, J. J.

AU - Jager, J. J.

AU - Borger, J. H.

AU - Scheijmans, L. J.

PY - 1999

Y1 - 1999

N2 - In two recent randomized clinical trials from Denmark and Canada the usefulness of radiotherapy was evaluated in premenopausal patients with breast cancer who had been operated and in whom the findings indicated a poor prognosis. Over 2000 patients participated. After follow-up periods of 10 and 15 years, respectively, addition of locoregional therapy to mastectomy and chemotherapy with cyclophosphamide, methotrexate and fluorouracil (CMF) was found to result in better locoregional control and a better disease-free survival. These studies also demonstrated, for the first time, that the overall survival was increased after postoperative radiotherapy. In view of these findings, the indication for postoperative locoregional radiotherapy in breast cancer in the Netherlands should be reconsidered

AB - In two recent randomized clinical trials from Denmark and Canada the usefulness of radiotherapy was evaluated in premenopausal patients with breast cancer who had been operated and in whom the findings indicated a poor prognosis. Over 2000 patients participated. After follow-up periods of 10 and 15 years, respectively, addition of locoregional therapy to mastectomy and chemotherapy with cyclophosphamide, methotrexate and fluorouracil (CMF) was found to result in better locoregional control and a better disease-free survival. These studies also demonstrated, for the first time, that the overall survival was increased after postoperative radiotherapy. In view of these findings, the indication for postoperative locoregional radiotherapy in breast cancer in the Netherlands should be reconsidered

M3 - Article

C2 - 10086106

SN - 0028-2162

VL - 143

SP - 71

EP - 73

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

IS - 2

ER -