TY - JOUR
T1 - Long-lasting reciprocal changes in striatal dopamine and acetylcholine release upon morphine withdrawal
AU - Guno Tjon Tien Ril, H. K.
AU - De Vries, Taco J.
AU - Wardeh, George
AU - Hogenboom, Francois
AU - Mulder, Arie H.
AU - Schoffelmeer, Anton N M
PY - 1993/4/28
Y1 - 1993/4/28
N2 - In superfused rat striatal slices, the electrically evoked release of [3]dopamine was reduced by about 30% and that of [14C]acetylcholine was enhanced by about 25% no less than 3 weeks after morphine withdrawal in rats chronically treated with the opiate for 6 days. The lasting nature of the reduced dopamine release at the level of dopaminergic nerve terminals and the concomittant enhanced excitability of neurons tonically inhibited by released dopamine, such as cholinergic interneurons, could play an important role in the maintenance of opiate dependence.
AB - In superfused rat striatal slices, the electrically evoked release of [3]dopamine was reduced by about 30% and that of [14C]acetylcholine was enhanced by about 25% no less than 3 weeks after morphine withdrawal in rats chronically treated with the opiate for 6 days. The lasting nature of the reduced dopamine release at the level of dopaminergic nerve terminals and the concomittant enhanced excitability of neurons tonically inhibited by released dopamine, such as cholinergic interneurons, could play an important role in the maintenance of opiate dependence.
KW - Acetylcholine release (striatal)
KW - Dopamine release (striatal)
KW - Morphine withdrawal
UR - http://www.scopus.com/inward/record.url?scp=0027310783&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/0014-2999(93)90155-B
DO - https://doi.org/10.1016/0014-2999(93)90155-B
M3 - Article
C2 - 8508912
SN - 0014-2999
VL - 235
SP - 321
EP - 322
JO - European journal of pharmacology
JF - European journal of pharmacology
IS - 2-3
ER -