TY - JOUR
T1 - Long-term height gain of prematurely born children with neonatal growth restraint
T2 - Parallellism with the growth pattern of short children born small for gestational age
AU - Finken, Martijn J. J.
AU - Dekker, Friedo W.
AU - de Zegher, Francis
AU - Wit, Jan M.
PY - 2006/8
Y1 - 2006/8
N2 - BACKGROUND. It is unknown whether children born very preterm (<32 weeks' gestation) with appropriate size for gestational age, who grow poorly in the first postnatal months (ie, preterm growth restraint), show a similar growth pattern as children born small for gestational age. OBJECTIVE. Childhood growth and adult height of children with preterm growth restraint were compared to those of very preterm small-for-gestational-age and non-preterm-growth-restraint children. METHODS. Data were drawn from the Project on Preterm and Small-for-Gestational-Age Infants cohort. Preterm growth restraint was considered to have occurred after appropriate-size-for-gestational-age birth and if length and/or weight was below -2 SD score at 3 months postterm. RESULTS. Among 380 very preterm children, 274 experienced no preterm growth restraint and showed near-normal growth, whereas 79 (21%) experienced preterm growth restraint and subsequently displayed a growth pattern similar to that of very preterm small-for-gestational-age children (n = 27). Adult height of these children was -1.1 to -1.2 SD score. Very preterm small-for-gestational-age and preterm-growth-restraint children with a height below -2 SD score at 5 years had an adult height of approximately -2.5 SD score. CONCLUSIONS. Childhood growth and adult height were similar in very preterm small-for-gestational-age and preterm-growth-restraint children. These long-term findings further strengthen the plausibility of extending the small-for-gestational-age indication for growth hormone therapy in such a way that preterm-growth-restraint children are no longer excluded if they have a short stature persisting beyond the age of ∼5 years. Copyright © 2006 by the American Academy of Pediatrics.
AB - BACKGROUND. It is unknown whether children born very preterm (<32 weeks' gestation) with appropriate size for gestational age, who grow poorly in the first postnatal months (ie, preterm growth restraint), show a similar growth pattern as children born small for gestational age. OBJECTIVE. Childhood growth and adult height of children with preterm growth restraint were compared to those of very preterm small-for-gestational-age and non-preterm-growth-restraint children. METHODS. Data were drawn from the Project on Preterm and Small-for-Gestational-Age Infants cohort. Preterm growth restraint was considered to have occurred after appropriate-size-for-gestational-age birth and if length and/or weight was below -2 SD score at 3 months postterm. RESULTS. Among 380 very preterm children, 274 experienced no preterm growth restraint and showed near-normal growth, whereas 79 (21%) experienced preterm growth restraint and subsequently displayed a growth pattern similar to that of very preterm small-for-gestational-age children (n = 27). Adult height of these children was -1.1 to -1.2 SD score. Very preterm small-for-gestational-age and preterm-growth-restraint children with a height below -2 SD score at 5 years had an adult height of approximately -2.5 SD score. CONCLUSIONS. Childhood growth and adult height were similar in very preterm small-for-gestational-age and preterm-growth-restraint children. These long-term findings further strengthen the plausibility of extending the small-for-gestational-age indication for growth hormone therapy in such a way that preterm-growth-restraint children are no longer excluded if they have a short stature persisting beyond the age of ∼5 years. Copyright © 2006 by the American Academy of Pediatrics.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33748422260&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/16882818
U2 - https://doi.org/10.1542/peds.2006-0103
DO - https://doi.org/10.1542/peds.2006-0103
M3 - Article
C2 - 16882818
SN - 0031-4005
VL - 118
SP - 640
EP - 643
JO - Pediatrics
JF - Pediatrics
IS - 2
ER -