TY - JOUR
T1 - Long-term impact of prenatal exposure to chemotherapy on executive functioning: An ERP study
AU - Blommaert, Jeroen
AU - Zink, Rob
AU - Deprez, Sabine
AU - Myatchin, Ivan
AU - Dupont, Patrick
AU - Vandenbroucke, Tineke
AU - Sleurs, Charlotte
AU - van Calsteren, Kristel
AU - Amant, Frédéric
AU - Lagae, Lieven
PY - 2019
Y1 - 2019
N2 - Objective: This study examines the long-term impact of prenatal exposure to chemotherapy on executive functioning and the contribution of late-prematurity to this effect, using event-related potentials. Methods: Mothers of the prenatal-exposed children (n = 20) were diagnosed with cancer and received chemotherapeutic treatment during pregnancy. We recruited healthy controls (n = 20) who were matched on a 1:1 ratio regarding prematurity, age and sex. We assessed executive functioning at the age of nine, using two event-related potential paradigms: a Go/Nogo paradigm to investigate processes of response inhibition and conflict monitoring, as well as a Posner paradigm to investigate spatial attention. Results: Lower potentials were found in prenatal-exposed children compared to controls in the Go/Nogo P3 and Posner positive slow wave. Moreover, prenatal-exposed children responded slower on the Posner paradigm compared to controls (p < .033), with more incorrect responses (p = .023). In the control group, the N2 Go/Nogo wave was more pronounced in children born after a longer gestation. Conclusions: This is the first study that demonstrates an effect of prenatal exposure to chemotherapy on the development of executive functioning, not limited to the effect of late-prematurity. Significance: This study emphasizes the necessity of a long-term follow-up of prenatal-exposed children to re-inform clinical practice on the costs and benefits of late-premature induction over treatment during pregnancy.
AB - Objective: This study examines the long-term impact of prenatal exposure to chemotherapy on executive functioning and the contribution of late-prematurity to this effect, using event-related potentials. Methods: Mothers of the prenatal-exposed children (n = 20) were diagnosed with cancer and received chemotherapeutic treatment during pregnancy. We recruited healthy controls (n = 20) who were matched on a 1:1 ratio regarding prematurity, age and sex. We assessed executive functioning at the age of nine, using two event-related potential paradigms: a Go/Nogo paradigm to investigate processes of response inhibition and conflict monitoring, as well as a Posner paradigm to investigate spatial attention. Results: Lower potentials were found in prenatal-exposed children compared to controls in the Go/Nogo P3 and Posner positive slow wave. Moreover, prenatal-exposed children responded slower on the Posner paradigm compared to controls (p < .033), with more incorrect responses (p = .023). In the control group, the N2 Go/Nogo wave was more pronounced in children born after a longer gestation. Conclusions: This is the first study that demonstrates an effect of prenatal exposure to chemotherapy on the development of executive functioning, not limited to the effect of late-prematurity. Significance: This study emphasizes the necessity of a long-term follow-up of prenatal-exposed children to re-inform clinical practice on the costs and benefits of late-premature induction over treatment during pregnancy.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85069606600&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31330451
U2 - https://doi.org/10.1016/j.clinph.2019.06.012
DO - https://doi.org/10.1016/j.clinph.2019.06.012
M3 - Article
C2 - 31330451
SN - 1388-2457
VL - 130
SP - 1655
EP - 1664
JO - Clinical neurophysiology
JF - Clinical neurophysiology
IS - 9
ER -