TY - JOUR
T1 - Longitudinal resting-state network connectivity changes in electroconvulsive therapy patients compared to healthy controls
AU - Verdijk, Joey P. A. J.
AU - van de Mortel, Laurens A.
AU - ten Doesschate, Freek
AU - Pottkämper, Julia C. M.
AU - Stuiver, Sven
AU - Bruin, Willem B.
AU - Abbott, Christopher C.
AU - Argyelan, Miklos
AU - Ousdal, Olga T.
AU - Bartsch, Hauke
AU - Narr, Katherine
AU - Tendolkar, Indira
AU - Calhoun, Vince
AU - Lukemire, Joshua
AU - Guo, Ying
AU - Oltedal, Leif
AU - van Wingen, Guido
AU - van Waarde, Jeroen A.
N1 - Publisher Copyright: © 2024
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Objective: Electroconvulsive therapy (ECT) is effective for major depressive episodes. Understanding of underlying mechanisms has been increased by examining changes of brain connectivity but studies often do not correct for test-retest variability in healthy controls (HC). In this study, we investigated changes in resting-state networks after ECT in a multicenter study. Methods: Functional resting-state magnetic resonance imaging data, acquired before start and within one week after ECT, from 90 depressed patients were analyzed, as well as longitudinal data of 24 HC. Group-information guided independent component analysis (GIG-ICA) was used to spatially restrict decomposition to twelve canonical resting-state networks. Selected networks of interest were the default mode network (DMN), salience network (SN), and left and right frontoparietal network (LFPN, and RFPN). Whole-brain voxel-wise analyses were used to assess group differences at baseline, group by time interactions, and correlations with treatment effectiveness. In addition, between-network connectivity and within-network strengths were computed. Results: Within-network strength of the DMN was lower at baseline in ECT patients which increased after ECT compared to HC, after which no differences were detected. At baseline, ECT patients showed lower whole-brain voxel-wise DMN connectivity in the precuneus. Increase of within-network strength of the LFPN was correlated with treatment effectiveness. We did not find whole-brain voxel-wise or between-network changes. Conclusion: DMN within-network connectivity normalized after ECT. Within-network increase of the LFPN in ECT patients was correlated with higher treatment effectiveness. In contrast to earlier studies, we found no whole-brain voxel-wise changes, which highlights the necessity to account for test-retest effects.
AB - Objective: Electroconvulsive therapy (ECT) is effective for major depressive episodes. Understanding of underlying mechanisms has been increased by examining changes of brain connectivity but studies often do not correct for test-retest variability in healthy controls (HC). In this study, we investigated changes in resting-state networks after ECT in a multicenter study. Methods: Functional resting-state magnetic resonance imaging data, acquired before start and within one week after ECT, from 90 depressed patients were analyzed, as well as longitudinal data of 24 HC. Group-information guided independent component analysis (GIG-ICA) was used to spatially restrict decomposition to twelve canonical resting-state networks. Selected networks of interest were the default mode network (DMN), salience network (SN), and left and right frontoparietal network (LFPN, and RFPN). Whole-brain voxel-wise analyses were used to assess group differences at baseline, group by time interactions, and correlations with treatment effectiveness. In addition, between-network connectivity and within-network strengths were computed. Results: Within-network strength of the DMN was lower at baseline in ECT patients which increased after ECT compared to HC, after which no differences were detected. At baseline, ECT patients showed lower whole-brain voxel-wise DMN connectivity in the precuneus. Increase of within-network strength of the LFPN was correlated with treatment effectiveness. We did not find whole-brain voxel-wise or between-network changes. Conclusion: DMN within-network connectivity normalized after ECT. Within-network increase of the LFPN in ECT patients was correlated with higher treatment effectiveness. In contrast to earlier studies, we found no whole-brain voxel-wise changes, which highlights the necessity to account for test-retest effects.
KW - BOLD imaging
KW - Functional networks
KW - Major depressive disorder
UR - http://www.scopus.com/inward/record.url?scp=85184741297&partnerID=8YFLogxK
U2 - 10.1016/j.brs.2023.12.005
DO - 10.1016/j.brs.2023.12.005
M3 - Article
C2 - 38101469
SN - 1935-861X
VL - 17
SP - 140
EP - 147
JO - Brain Stimulation
JF - Brain Stimulation
IS - 1
ER -