Look-back study of infectivity of anti-HCV ELISA-positive blood components

H. Vrielink; C. L. van der Poel; H. W. Reesink; H. L. Zaaijer; E. Scholten; L. C. Kremer; H. T. Cuypers; P. N. Lelie; M. H. van Oers

doi:https://doi.org/10.1016/S0140-6736(95)90063-2

Look-back study of infectivity of anti-HCV ELISA-positive blood components

H. Vrielink, C. L. van der Poel, H. W. Reesink, H. L. Zaaijer, E. Scholten, L. C. Kremer, H. T. Cuypers, P. N. Lelie, M. H. van Oers

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Abstract

The infectivity of blood components from donors who were later found to be anti-HCV ELISA-positive was investigated in recipients who were enrolled in a look-back programme. Recipients received ELISA-positive blood components from donors who were PCR-positive and/or RIBA-2-positive (n = 22, group A) or PCR-negative and indeterminate or negative on RIBA-2 (n = 105, group B). 26 of 32 (81%) recipients of group A donors and none of 140 of group B were HCV-infected. All stored serum samples of previous donations (n = 172) of group A donors were anti-HCV-positive in RIBA-3, indicating a chronic carrier state of HCV in these donors

Original language	English
Pages (from-to)	95-96
Journal	Lancet
Volume	345
Issue number	8942
DOIs	https://doi.org/10.1016/S0140-6736(95)90063-2
Publication status	Published - 1995

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https://doi.org/10.1016/S0140-6736(95)90063-2

Cite this

@article{805951c2859a41d9940bfec13a4b0a7d,

title = "Look-back study of infectivity of anti-HCV ELISA-positive blood components",

abstract = "The infectivity of blood components from donors who were later found to be anti-HCV ELISA-positive was investigated in recipients who were enrolled in a look-back programme. Recipients received ELISA-positive blood components from donors who were PCR-positive and/or RIBA-2-positive (n = 22, group A) or PCR-negative and indeterminate or negative on RIBA-2 (n = 105, group B). 26 of 32 (81%) recipients of group A donors and none of 140 of group B were HCV-infected. All stored serum samples of previous donations (n = 172) of group A donors were anti-HCV-positive in RIBA-3, indicating a chronic carrier state of HCV in these donors",

author = "H. Vrielink and {van der Poel}, {C. L.} and Reesink, {H. W.} and Zaaijer, {H. L.} and E. Scholten and Kremer, {L. C.} and Cuypers, {H. T.} and Lelie, {P. N.} and {van Oers}, {M. H.}",

year = "1995",

doi = "https://doi.org/10.1016/S0140-6736(95)90063-2",

language = "English",

volume = "345",

pages = "95--96",

journal = "Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "8942",

}

TY - JOUR

T1 - Look-back study of infectivity of anti-HCV ELISA-positive blood components

AU - Vrielink, H.

AU - van der Poel, C. L.

AU - Reesink, H. W.

AU - Zaaijer, H. L.

AU - Scholten, E.

AU - Kremer, L. C.

AU - Cuypers, H. T.

AU - Lelie, P. N.

AU - van Oers, M. H.

PY - 1995

Y1 - 1995

N2 - The infectivity of blood components from donors who were later found to be anti-HCV ELISA-positive was investigated in recipients who were enrolled in a look-back programme. Recipients received ELISA-positive blood components from donors who were PCR-positive and/or RIBA-2-positive (n = 22, group A) or PCR-negative and indeterminate or negative on RIBA-2 (n = 105, group B). 26 of 32 (81%) recipients of group A donors and none of 140 of group B were HCV-infected. All stored serum samples of previous donations (n = 172) of group A donors were anti-HCV-positive in RIBA-3, indicating a chronic carrier state of HCV in these donors

AB - The infectivity of blood components from donors who were later found to be anti-HCV ELISA-positive was investigated in recipients who were enrolled in a look-back programme. Recipients received ELISA-positive blood components from donors who were PCR-positive and/or RIBA-2-positive (n = 22, group A) or PCR-negative and indeterminate or negative on RIBA-2 (n = 105, group B). 26 of 32 (81%) recipients of group A donors and none of 140 of group B were HCV-infected. All stored serum samples of previous donations (n = 172) of group A donors were anti-HCV-positive in RIBA-3, indicating a chronic carrier state of HCV in these donors

U2 - https://doi.org/10.1016/S0140-6736(95)90063-2

DO - https://doi.org/10.1016/S0140-6736(95)90063-2

M3 - Comment/Letter to the editor

C2 - 7815889

SN - 0140-6736

VL - 345

SP - 95

EP - 96

JO - Lancet

JF - Lancet

IS - 8942

ER -