Losartan in Marfan syndrome

A.W. den Hartog

Losartan in Marfan syndrome

Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

Abstract

Marfan syndrome (MFS) is a multisystemic disorder of the connective tissue with a prevalence of 1 per 5000 and is caused by mutations in the FBN1 gene. Cardiovascular characteristics of MFS include aortic dilatation, aortic dissection and a diminished ventricular function. Transforming growth factor–β (TGF-β) signaling is upregulated in mice with a FBN1 mutation and treatment of these mice with losartan attenuates TGF-β signaling, prevents aortic media degeneration and aortic dilatation.
This thesis focuses on aortic dilatation, ventricular function and type B aortic dissection in adults with MFS and the effect of losartan on these cardinal features.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution
Supervisors/Advisors	Mulder, Barbara, Supervisor Zwinderman, Koos, Supervisor Groenink, maarten, Co-supervisor de Waard, Vivian, Co-supervisor
Award date	9 May 2017
Print ISBNs	9789492683199
Publication status	Published - 2017

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title = "Losartan in Marfan syndrome",

abstract = "Marfan syndrome (MFS) is a multisystemic disorder of the connective tissue with a prevalence of 1 per 5000 and is caused by mutations in the FBN1 gene. Cardiovascular characteristics of MFS include aortic dilatation, aortic dissection and a diminished ventricular function. Transforming growth factor–β (TGF-β) signaling is upregulated in mice with a FBN1 mutation and treatment of these mice with losartan attenuates TGF-β signaling, prevents aortic media degeneration and aortic dilatation. This thesis focuses on aortic dilatation, ventricular function and type B aortic dissection in adults with MFS and the effect of losartan on these cardinal features.",

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year = "2017",

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AU - den Hartog, A.W.

PY - 2017

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N2 - Marfan syndrome (MFS) is a multisystemic disorder of the connective tissue with a prevalence of 1 per 5000 and is caused by mutations in the FBN1 gene. Cardiovascular characteristics of MFS include aortic dilatation, aortic dissection and a diminished ventricular function. Transforming growth factor–β (TGF-β) signaling is upregulated in mice with a FBN1 mutation and treatment of these mice with losartan attenuates TGF-β signaling, prevents aortic media degeneration and aortic dilatation. This thesis focuses on aortic dilatation, ventricular function and type B aortic dissection in adults with MFS and the effect of losartan on these cardinal features.

AB - Marfan syndrome (MFS) is a multisystemic disorder of the connective tissue with a prevalence of 1 per 5000 and is caused by mutations in the FBN1 gene. Cardiovascular characteristics of MFS include aortic dilatation, aortic dissection and a diminished ventricular function. Transforming growth factor–β (TGF-β) signaling is upregulated in mice with a FBN1 mutation and treatment of these mice with losartan attenuates TGF-β signaling, prevents aortic media degeneration and aortic dilatation. This thesis focuses on aortic dilatation, ventricular function and type B aortic dissection in adults with MFS and the effect of losartan on these cardinal features.

UR - https://pure.uva.nl/ws/files/12016827/License_agreement_co_signed_.pdf

M3 - Phd-Thesis - Research and graduation internal

SN - 9789492683199

ER -

Losartan in Marfan syndrome

Abstract

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