Lower cognitive function in older patients with lower muscle strength and muscle mass

Romee van Dam, Jeanine M. van Ancum, Sjors Verlaan, Kira Scheerman, Carel G. M. Meskers, Andrea B. Maier

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)


Background: Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients. Methods: This prospective inception cohort included 378 patients aged 70 years or older. At admission patients were assessed for cognitive functioning by use of the Six-Item Cognitive Impairment Test (6-CIT). Muscle strength and muscle mass were assessed using handheld dynamometry and segmental multifrequency bioelectrical impedance analysis, within 48 h after admission and on day 7, or earlier on the day of discharge. Results: The data of 371 patients (mean age ± standard deviation 80.1 ± 6.4 years, 49.3% female) were available for analyses. The median (interquartile range) 6-CIT score was 4 (0-8) points. At admission, lower cognitive functioning was associated with lower muscle strength, lower skeletal muscle mass (SMM), lower appendicular lean mass, and lower SMM index. Cognitive functioning was not associated with change in muscle strength and muscle mass during hospitalization. Conclusion: This study further strengthens evidence for an association between lower cognitive functioning and lower muscle strength and muscle mass, but without a further decline during hospitalization.
Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalDementia and geriatric cognitive disorders
Issue number3-4
Early online date18 Jun 2018
Publication statusPublished - Jul 2018


  • Aged
  • Aged, 80 and over
  • Cognition
  • Cognitive Dysfunction/diagnosis
  • Female
  • Geriatric Assessment/methods
  • Hospitalization/statistics & numerical data
  • Humans
  • Male
  • Muscle Strength
  • Muscle Weakness/diagnosis
  • Muscle, Skeletal/pathology
  • Netherlands
  • Prospective Studies
  • Statistics as Topic

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