TY - JOUR
T1 - Lower cognitive function in older patients with lower muscle strength and muscle mass
AU - van Dam, Romee
AU - van Ancum, Jeanine M.
AU - Verlaan, Sjors
AU - Scheerman, Kira
AU - Meskers, Carel G. M.
AU - Maier, Andrea B.
N1 - © 2018 The Author(s) Published by S. Karger AG, Basel.
PY - 2018/7
Y1 - 2018/7
N2 - Background: Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients. Methods: This prospective inception cohort included 378 patients aged 70 years or older. At admission patients were assessed for cognitive functioning by use of the Six-Item Cognitive Impairment Test (6-CIT). Muscle strength and muscle mass were assessed using handheld dynamometry and segmental multifrequency bioelectrical impedance analysis, within 48 h after admission and on day 7, or earlier on the day of discharge. Results: The data of 371 patients (mean age ± standard deviation 80.1 ± 6.4 years, 49.3% female) were available for analyses. The median (interquartile range) 6-CIT score was 4 (0-8) points. At admission, lower cognitive functioning was associated with lower muscle strength, lower skeletal muscle mass (SMM), lower appendicular lean mass, and lower SMM index. Cognitive functioning was not associated with change in muscle strength and muscle mass during hospitalization. Conclusion: This study further strengthens evidence for an association between lower cognitive functioning and lower muscle strength and muscle mass, but without a further decline during hospitalization.
AB - Background: Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients. Methods: This prospective inception cohort included 378 patients aged 70 years or older. At admission patients were assessed for cognitive functioning by use of the Six-Item Cognitive Impairment Test (6-CIT). Muscle strength and muscle mass were assessed using handheld dynamometry and segmental multifrequency bioelectrical impedance analysis, within 48 h after admission and on day 7, or earlier on the day of discharge. Results: The data of 371 patients (mean age ± standard deviation 80.1 ± 6.4 years, 49.3% female) were available for analyses. The median (interquartile range) 6-CIT score was 4 (0-8) points. At admission, lower cognitive functioning was associated with lower muscle strength, lower skeletal muscle mass (SMM), lower appendicular lean mass, and lower SMM index. Cognitive functioning was not associated with change in muscle strength and muscle mass during hospitalization. Conclusion: This study further strengthens evidence for an association between lower cognitive functioning and lower muscle strength and muscle mass, but without a further decline during hospitalization.
KW - Aged
KW - Aged, 80 and over
KW - Cognition
KW - Cognitive Dysfunction/diagnosis
KW - Female
KW - Geriatric Assessment/methods
KW - Hospitalization/statistics & numerical data
KW - Humans
KW - Male
KW - Muscle Strength
KW - Muscle Weakness/diagnosis
KW - Muscle, Skeletal/pathology
KW - Netherlands
KW - Prospective Studies
KW - Statistics as Topic
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048870237&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29913450
UR - http://www.scopus.com/inward/record.url?scp=85048870237&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048870237&partnerID=8YFLogxK
U2 - https://doi.org/10.1159/000486711
DO - https://doi.org/10.1159/000486711
M3 - Article
C2 - 29913450
SN - 1420-8008
VL - 45
SP - 243
EP - 250
JO - Dementia and geriatric cognitive disorders
JF - Dementia and geriatric cognitive disorders
IS - 3-4
ER -