Lymphokine-mediated stimulation of eosinophil migration in the guinea-pig

W B van den Berg, J van Tuyl, P Sminia, T M Jentjens, R J Scheper

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Guinea-pig lymphokines were shown to stimulate the migration of eosinophils from capillary tubes. Eosinophil migration stimulatory activity was produced by Freund's complete adjuvant (FCA)-sensitized lymph node or peritoneal exudate lymphocytes in the presence of purified protein derivative (PPD), as well as by Con A-stimulated lymph node lymphocytes. Like murine and human eosinophil-stimulation promoter lymphokine (ESP), the guinea-pig lymphokine activity is T cell-derived, non-dialysable and resistant to heating at 56 degrees. In contrast to the migration inhibition factor (MIF) which could be adsorbed by macrophages, eosinophil migration stimulatory activity could not be removed by pre-adsorption to macrophages or eosinophils.

Original languageEnglish
Pages (from-to)481-8
Number of pages8
Issue number3
Publication statusPublished - Nov 1981


  • Adsorption
  • Animals
  • Cell Movement
  • Concanavalin A/pharmacology
  • Dialysis
  • Eosinophils/physiology
  • Female
  • Guinea Pigs
  • Hot Temperature
  • Lymphokines/pharmacology
  • Macrophages/physiology
  • Tuberculin

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