TY - JOUR
T1 - Lymphomatoid papulosis with a natural killer-cell phenotype
AU - Bekkenk, M. W.
AU - Kluin, P. M.
AU - Jansen, P. M.
AU - Meijer, C. J.
AU - Willemze, R.
PY - 2001
Y1 - 2001
N2 - Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/-, CD4+/-, CD8-, CD30+, CD56- T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3-, CD4-, CD8-, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype
AB - Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/-, CD4+/-, CD8-, CD30+, CD56- T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3-, CD4-, CD8-, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype
U2 - https://doi.org/10.1046/j.1365-2133.2001.04324.x
DO - https://doi.org/10.1046/j.1365-2133.2001.04324.x
M3 - Article
C2 - 11531801
SN - 0007-0963
VL - 145
SP - 318
EP - 322
JO - British Journal of Dermatology
JF - British Journal of Dermatology
IS - 2
ER -