TY - JOUR
T1 - Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain death
AU - Treckmann, Jürgen
AU - Moers, Cyril
AU - Smits, Jacqueline M.
AU - Gallinat, Anja
AU - Maathuis, Mark-Hugo J.
AU - van Kasterop-Kutz, Margitta
AU - Jochmans, Ina
AU - Homan van der Heide, Jaap J.
AU - Squifflet, Jean-Paul
AU - van Heurn, Ernest
AU - Kirste, Günter R.
AU - Rahmel, Axel
AU - Leuvenink, Henri G. D.
AU - Pirenne, Jacques
AU - Ploeg, Rutger J.
AU - Paul, Andreas
PY - 2011
Y1 - 2011
N2 - The purpose of this study was to analyze the possible effects of machine perfusion (MP) versus cold storage (CS) on delayed graft function (DGF) and early graft survival in expanded criteria donor kidneys (ECD). As part of the previously reported international randomized controlled trial 91 consecutive heart-beating deceased ECDs--defined according to the United Network of Organ Sharing definition--were included in the study. From each donor one kidney was randomized to MP and the contralateral kidney to CS. All recipients were followed for 1 year. The primary endpoint was DGF. Secondary endpoints included primary nonfunction and graft survival. DGF occurred in 27 patients in the CS group (29.7%) and in 20 patients in the MP group (22%). Using the logistic regression model MP significantly reduced the risk of DGF compared with CS (OR 0.460, P=0.047). The incidence of nonfunction in the CS group (12%) was four times higher than in the MP group (3%) (P=0.04). One-year graft survival was significantly higher in machine perfused kidneys compared with cold stored kidneys (92.3% vs. 80.2%, P=0.02). In the present study, MP preservation clearly reduced the risk of DGF and improved 1-year graft survival and function in ECD kidneys. (Current Controlled Trials number: ISRCTN83876362)
AB - The purpose of this study was to analyze the possible effects of machine perfusion (MP) versus cold storage (CS) on delayed graft function (DGF) and early graft survival in expanded criteria donor kidneys (ECD). As part of the previously reported international randomized controlled trial 91 consecutive heart-beating deceased ECDs--defined according to the United Network of Organ Sharing definition--were included in the study. From each donor one kidney was randomized to MP and the contralateral kidney to CS. All recipients were followed for 1 year. The primary endpoint was DGF. Secondary endpoints included primary nonfunction and graft survival. DGF occurred in 27 patients in the CS group (29.7%) and in 20 patients in the MP group (22%). Using the logistic regression model MP significantly reduced the risk of DGF compared with CS (OR 0.460, P=0.047). The incidence of nonfunction in the CS group (12%) was four times higher than in the MP group (3%) (P=0.04). One-year graft survival was significantly higher in machine perfused kidneys compared with cold stored kidneys (92.3% vs. 80.2%, P=0.02). In the present study, MP preservation clearly reduced the risk of DGF and improved 1-year graft survival and function in ECD kidneys. (Current Controlled Trials number: ISRCTN83876362)
U2 - https://doi.org/10.1111/j.1432-2277.2011.01232.x
DO - https://doi.org/10.1111/j.1432-2277.2011.01232.x
M3 - Article
C2 - 21332580
SN - 0934-0874
VL - 24
SP - 548
EP - 554
JO - Transplant international
JF - Transplant international
IS - 6
ER -