TY - JOUR
T1 - Macrophage Activation in Follicular Conjunctivitis during the COVID-19 Pandemic
AU - Gallenga, Carla Enrica
AU - Maritati, Martina
AU - Mura, Marco
AU - di Virgilio, Francesco
AU - Conti, Pio
AU - Contini, Carlo
N1 - Funding Information: Supported by institutional funds from the University of Ferrara to F.D.V. Publisher Copyright: © 2023 by the authors.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Among the symptoms of SARS-CoV-2, follicular conjunctivitis has become relevant. The conjunctiva acts as an open lymph node, reacting to the viral antigen that binds the epithelial cells, forming follicles of B cells with activated T cells and NK cells on its surface, which, in turn, talk to monocyte-derived inflammatory infected macrophages. Here, the NLRP3 inflammasome is a major driver in releasing pro-inflammatory factors such as IL-6 and caspase-1, leading to follicular conjunctivitis and bulbar congestion, even as isolated signs in the ‘asymptomatic’ patient.
AB - Among the symptoms of SARS-CoV-2, follicular conjunctivitis has become relevant. The conjunctiva acts as an open lymph node, reacting to the viral antigen that binds the epithelial cells, forming follicles of B cells with activated T cells and NK cells on its surface, which, in turn, talk to monocyte-derived inflammatory infected macrophages. Here, the NLRP3 inflammasome is a major driver in releasing pro-inflammatory factors such as IL-6 and caspase-1, leading to follicular conjunctivitis and bulbar congestion, even as isolated signs in the ‘asymptomatic’ patient.
KW - ACE2&TMPRSS2
KW - COVID-19
KW - P2X7R
KW - follicular conjunctivitis
KW - macrophages and activated T cells
UR - http://www.scopus.com/inward/record.url?scp=85172808266&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/microorganisms11092198
DO - https://doi.org/10.3390/microorganisms11092198
M3 - Article
C2 - 37764042
SN - 2076-2607
VL - 11
JO - Microorganisms
JF - Microorganisms
IS - 9
M1 - 2198
ER -