TY - JOUR
T1 - Macrovascular and renal microvascular complications in West Africans with intermediate hyperglycemia living in West Africa and Europe
T2 - The RODAM study
AU - Bannerman-Williams, Emmanuel
AU - Hayfron-Benjamin, Charles F.
AU - Atiase, Yacoba
AU - Bahendeka, Silver
AU - Meeks, Karlijn
AU - Klipstein-Grobusch, Kerstin
AU - Addo, Juliet
AU - Mockenhaupt, Frank
AU - Schulze, Matthias B.
AU - Beune, Erik
AU - van den Born, Bert-Jan
AU - Agyemang, Charles
N1 - Funding Information: Karlijn Meeks is supported by the Intramural Research Program of the National Human Genome Research Institute of the National Institutes of Health (NIH) through the Center for Research on Genomics and Global Health (CRGGH). The CRGGH was supported by the National Institute of Diabetes and Digestive and Kidney Diseases and the Office of the Director at the NIH ( Z01HG200362 ). Funding Information: This work was supported by the European Commission under the Framework Programme (Grant Number: 278901 ). The study sponsor was not involved in the design of the study; the collection, analysis, and interpretation of data; writing the report; nor the decision to submit the report for publication. Karlijn Meeks. is supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute , the National Institute of Diabetes and Digestive and Kidney Diseases , the Center for Information Technology, and the Office of the Director at the National Institutes of Health ( 1ZIAHG200362 ). Funding Information: This work was supported by the European Commission under the Framework Programme (Grant Number: 278901). The study sponsor was not involved in the design of the study; the collection, analysis, and interpretation of data; writing the report; nor the decision to submit the report for publication. Karlijn Meeks. is supported by the Intramural Research Program of the National Institutes of Health in the Center for Research on Genomics and Global Health (CRGGH). The CRGGH is supported by the National Human Genome Research Institute, the National Institute of Diabetes and Digestive and Kidney Diseases, the Center for Information Technology, and the Office of the Director at the National Institutes of Health (1ZIAHG200362).We are grateful to the research assistants, interviewers, and other staff of the 5 research locations who have taken part in gathering the data and, most of all, the Ghanaian volunteers participating in the RODAM study (Research on Obesity and Diabetes Among African Migrants). We gratefully acknowledge the advisory board members for their valuable support in shaping the RODAM study methods, Jan van Straalen from the Amsterdam University Medical Centre with standardization of the laboratory procedures, and the Amsterdam University Medical Centre Biobank for their support in biobank management and high-quality storage of collected samples. Karlijn Meeks is supported by the Intramural Research Program of the National Human Genome Research Institute of the National Institutes of Health (NIH) through the Center for Research on Genomics and Global Health (CRGGH). The CRGGH was supported by the National Institute of Diabetes and Digestive and Kidney Diseases and the Office of the Director at the NIH (Z01HG200362). Publisher Copyright: © 2023
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Background: Metabolic conditions, including intermediate hyperglycemia (IH), affect migrants to a greater extent than the populations of origin. Evidence suggests that IH increases the risk of vascular complications, but it is unclear whether the differences in IH between the non-migrant and migrant populations translate to differences in vascular complications between the two populations. We compared the prevalence of macrovascular and renal microvascular complications among West Africans with IH living in West Africa and their migrant compatriots in Europe. Methods: Data from the multicenter Research on Obesity and Diabetes among African Migrants(RODAM) study were analyzed. Ghanaians with IH(524 non-migrant and 1439 migrants) were included. Logistic regression analyses were used to determine the associations between migrant status and macrovascular [coronary artery disease(CAD) and peripheral artery disease(PAD)] and renal microvascular[nephropathy] complications with adjustment for age, sex, socioeconomic status, smoking, systolic blood pressure, BMI, total cholesterol, HbA1c, C-reactive protein, and serum uric acid. Findings: The prevalence of microvascular/macrovascular complications was higher in non-migrants than in migrants(nephropathy 15.3vs.9.7%; PAD 3.1%vs.1.3%; and CAD 15.8% vs. 5.0%). The differences persisted in the fully adjusted model: nephropathy [odds ratio, 2.12; 95% CI(1.46–3.08); PAD, 4.44(1.87–10.51); CAD 2.35(1.64–3.37)]. Non-migrant females had higher odds of nephropathy[2.14(1.34–3.43)], PAD[7.47(2.38–23.40)] and CAD [2.10(1.34–3.27)] compared to migrant females. Non-migrant males had higher odds of nephropathy[2.54(1.30–4.97)] and CAD[2.85(1.48–5.50)], but not PAD[1.81(0.32–10.29)],than their migrant peers. Interpretation: Macrovascular and renal microvascular complications were more prevalent in non-migrants than in migrant West Africans with IH. Further studies are needed to identify factors that increase the risk to aid preventive/treatment strategies.
AB - Background: Metabolic conditions, including intermediate hyperglycemia (IH), affect migrants to a greater extent than the populations of origin. Evidence suggests that IH increases the risk of vascular complications, but it is unclear whether the differences in IH between the non-migrant and migrant populations translate to differences in vascular complications between the two populations. We compared the prevalence of macrovascular and renal microvascular complications among West Africans with IH living in West Africa and their migrant compatriots in Europe. Methods: Data from the multicenter Research on Obesity and Diabetes among African Migrants(RODAM) study were analyzed. Ghanaians with IH(524 non-migrant and 1439 migrants) were included. Logistic regression analyses were used to determine the associations between migrant status and macrovascular [coronary artery disease(CAD) and peripheral artery disease(PAD)] and renal microvascular[nephropathy] complications with adjustment for age, sex, socioeconomic status, smoking, systolic blood pressure, BMI, total cholesterol, HbA1c, C-reactive protein, and serum uric acid. Findings: The prevalence of microvascular/macrovascular complications was higher in non-migrants than in migrants(nephropathy 15.3vs.9.7%; PAD 3.1%vs.1.3%; and CAD 15.8% vs. 5.0%). The differences persisted in the fully adjusted model: nephropathy [odds ratio, 2.12; 95% CI(1.46–3.08); PAD, 4.44(1.87–10.51); CAD 2.35(1.64–3.37)]. Non-migrant females had higher odds of nephropathy[2.14(1.34–3.43)], PAD[7.47(2.38–23.40)] and CAD [2.10(1.34–3.27)] compared to migrant females. Non-migrant males had higher odds of nephropathy[2.54(1.30–4.97)] and CAD[2.85(1.48–5.50)], but not PAD[1.81(0.32–10.29)],than their migrant peers. Interpretation: Macrovascular and renal microvascular complications were more prevalent in non-migrants than in migrant West Africans with IH. Further studies are needed to identify factors that increase the risk to aid preventive/treatment strategies.
KW - Diabetes complications
KW - Intermediate hyperglycemia
KW - Macrovascular complications
KW - Microvascular complications
KW - Prediabetes
KW - RODAM study
KW - Sub-saharan africa
UR - http://www.scopus.com/inward/record.url?scp=85168447689&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.heliyon.2023.e19334
DO - https://doi.org/10.1016/j.heliyon.2023.e19334
M3 - Article
C2 - 37664733
SN - 2405-8440
VL - 9
JO - Heliyon
JF - Heliyon
IS - 8
M1 - e19334
ER -