TY - JOUR
T1 - Macular dystrophies mimicking age-related macular degeneration
AU - Saksens, Nicole T. M.
AU - Fleckenstein, Monika
AU - Schmitz-Valckenberg, Steffen
AU - Holz, Frank G.
AU - den Hollander, Anneke I.
AU - Keunen, Jan E. E.
AU - Boon, Camiel J. F.
AU - Hoyng, Carel B.
PY - 2014/3
Y1 - 2014/3
N2 - Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population in the Western world. AMD is a clinically heterogeneous disease presenting with drusen, pigmentary changes, geographic atrophy and/or choroidal neovascularization. Due to its heterogeneous presentation, it can be challenging to distinguish AMD from several macular diseases that can mimic the features of AMD. This clinical overlap may potentially lead to misdiagnosis. In this review, we discuss the characteristics of AMD and the macular dystrophies that can mimic AMD. The appropriate use of clinical and genetic analysis can aid the clinician to establish the correct diagnosis, and to provide the patient with the appropriate prognostic information. An overview is presented of overlapping and distinguishing clinical features. © 2013 Elsevier Ltd.
AB - Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population in the Western world. AMD is a clinically heterogeneous disease presenting with drusen, pigmentary changes, geographic atrophy and/or choroidal neovascularization. Due to its heterogeneous presentation, it can be challenging to distinguish AMD from several macular diseases that can mimic the features of AMD. This clinical overlap may potentially lead to misdiagnosis. In this review, we discuss the characteristics of AMD and the macular dystrophies that can mimic AMD. The appropriate use of clinical and genetic analysis can aid the clinician to establish the correct diagnosis, and to provide the patient with the appropriate prognostic information. An overview is presented of overlapping and distinguishing clinical features. © 2013 Elsevier Ltd.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84893787933&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/24291520
U2 - https://doi.org/10.1016/j.preteyeres.2013.11.001
DO - https://doi.org/10.1016/j.preteyeres.2013.11.001
M3 - Review article
C2 - 24291520
SN - 1350-9462
VL - 39
SP - 23
EP - 57
JO - Progress in Retinal and Eye Research
JF - Progress in Retinal and Eye Research
ER -