Macular dystrophies mimicking age-related macular degeneration

Nicole T. M. Saksens, Monika Fleckenstein, Steffen Schmitz-Valckenberg, Frank G. Holz, Anneke I. den Hollander, Jan E. E. Keunen, Camiel J. F. Boon, Carel B. Hoyng

Research output: Contribution to journalReview articleAcademicpeer-review

70 Citations (Scopus)

Abstract

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population in the Western world. AMD is a clinically heterogeneous disease presenting with drusen, pigmentary changes, geographic atrophy and/or choroidal neovascularization. Due to its heterogeneous presentation, it can be challenging to distinguish AMD from several macular diseases that can mimic the features of AMD. This clinical overlap may potentially lead to misdiagnosis. In this review, we discuss the characteristics of AMD and the macular dystrophies that can mimic AMD. The appropriate use of clinical and genetic analysis can aid the clinician to establish the correct diagnosis, and to provide the patient with the appropriate prognostic information. An overview is presented of overlapping and distinguishing clinical features. © 2013 Elsevier Ltd.
Original languageEnglish
Pages (from-to)23-57
JournalProgress in Retinal and Eye Research
Volume39
DOIs
Publication statusPublished - Mar 2014
Externally publishedYes

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