TY - JOUR
T1 - Magnetic and fluorescent nanoparticles for multimodality imaging
AU - Mulder, Willem J. M.
AU - Griffioen, Arjan W.
AU - Strijkers, Gustav J.
AU - Cormode, David P.
AU - Nicolay, Klaas
AU - Fayad, Zahi A.
PY - 2007
Y1 - 2007
N2 - The development of nanoparticulate contrast agents is providing an increasing contribution to the field of diagnostic and molecular imaging. Such agents provide several advantages over traditional compounds. First, they may contain a high payload of the contrast-generating material, which greatly improves their detectability. Second, multiple properties may be easily integrated within one nanoparticle to allow its detection with several imaging techniques or to include therapeutic qualities. Finally, the surface of such nanoparticles may be modified to improve circulation half-lives or to attach targeting groups. Magnetic resonance imaging and optical techniques are highly complementary imaging methods. Combining these techniques would therefore have significant advantages and may be realized through the use of nanoparticulate contrast agents. This review gives a survey of the different types of fluorescent and magnetic nanoparticles that have been employed for both magnetic resonance and optical imaging studies
AB - The development of nanoparticulate contrast agents is providing an increasing contribution to the field of diagnostic and molecular imaging. Such agents provide several advantages over traditional compounds. First, they may contain a high payload of the contrast-generating material, which greatly improves their detectability. Second, multiple properties may be easily integrated within one nanoparticle to allow its detection with several imaging techniques or to include therapeutic qualities. Finally, the surface of such nanoparticles may be modified to improve circulation half-lives or to attach targeting groups. Magnetic resonance imaging and optical techniques are highly complementary imaging methods. Combining these techniques would therefore have significant advantages and may be realized through the use of nanoparticulate contrast agents. This review gives a survey of the different types of fluorescent and magnetic nanoparticles that have been employed for both magnetic resonance and optical imaging studies
U2 - https://doi.org/10.2217/17435889.2.3.307
DO - https://doi.org/10.2217/17435889.2.3.307
M3 - Review article
C2 - 17716176
SN - 1743-5889
VL - 2
SP - 307
EP - 324
JO - Nanomedicine (London, England)
JF - Nanomedicine (London, England)
IS - 3
ER -