Magnetic resonance imaging of vulnerable atherosclerotic plaques: current imaging strategies and molecular imaging probes

Karen C. Briley-Saebo; Willem J. M. Mulder; Venkatesh Mani; Fabien Hyafil; Vardan Amirbekian; Juan Gilberto S. Aguinaldo; Edward A. Fisher; Zahi A. Fayad

doi:https://doi.org/10.1002/jmri.20989

Magnetic resonance imaging of vulnerable atherosclerotic plaques: current imaging strategies and molecular imaging probes

Karen C. Briley-Saebo, Willem J. M. Mulder, Venkatesh Mani, Fabien Hyafil, Vardan Amirbekian, Juan Gilberto S. Aguinaldo, Edward A. Fisher, Zahi A. Fayad

Medical Biochemistry (AMC)

Research output: Contribution to journal › Review article › Academic › peer-review

117 Citations (Scopus)

Abstract

The vulnerability or destabilization of atherosclerotic plaques has been directly linked to plaque composition. Imaging modalities, such as magnetic resonance (MR) imaging, that allow for evaluation of plaque composition at a cellular and molecular level, could further improve the detection of vulnerable plaque and may allow for monitoring the efficacy of antiatherosclerotic therapies. In this review we focus on MR imaging strategies for the detection and evaluation of atherosclerotic plaques and their composition. We highlight recent advancements in the development of MR pulse sequences, computer image analysis, and the use of commercially available MR contrast agents, such as gadopentic acid (Gd-DTPA), for plaque characterization. We also discuss molecular imaging strategies that are currently being used to design specific imaging probes targeted to biochemical and cellular markers of atherosclerotic plaque vulnerability

Original language	English
Pages (from-to)	460-479
Journal	Journal of magnetic resonance imaging
Volume	26
Issue number	3
DOIs	https://doi.org/10.1002/jmri.20989
Publication status	Published - 2007

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https://doi.org/10.1002/jmri.20989

Cite this

@article{23223bbd7c844428baa39b1e2de64ac0,

title = "Magnetic resonance imaging of vulnerable atherosclerotic plaques: current imaging strategies and molecular imaging probes",

abstract = "The vulnerability or destabilization of atherosclerotic plaques has been directly linked to plaque composition. Imaging modalities, such as magnetic resonance (MR) imaging, that allow for evaluation of plaque composition at a cellular and molecular level, could further improve the detection of vulnerable plaque and may allow for monitoring the efficacy of antiatherosclerotic therapies. In this review we focus on MR imaging strategies for the detection and evaluation of atherosclerotic plaques and their composition. We highlight recent advancements in the development of MR pulse sequences, computer image analysis, and the use of commercially available MR contrast agents, such as gadopentic acid (Gd-DTPA), for plaque characterization. We also discuss molecular imaging strategies that are currently being used to design specific imaging probes targeted to biochemical and cellular markers of atherosclerotic plaque vulnerability",

author = "Briley-Saebo, {Karen C.} and Mulder, {Willem J. M.} and Venkatesh Mani and Fabien Hyafil and Vardan Amirbekian and Aguinaldo, {Juan Gilberto S.} and Fisher, {Edward A.} and Fayad, {Zahi A.}",

year = "2007",

doi = "https://doi.org/10.1002/jmri.20989",

language = "English",

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pages = "460--479",

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TY - JOUR

T1 - Magnetic resonance imaging of vulnerable atherosclerotic plaques: current imaging strategies and molecular imaging probes

AU - Briley-Saebo, Karen C.

AU - Mulder, Willem J. M.

AU - Mani, Venkatesh

AU - Hyafil, Fabien

AU - Amirbekian, Vardan

AU - Aguinaldo, Juan Gilberto S.

AU - Fisher, Edward A.

AU - Fayad, Zahi A.

PY - 2007

Y1 - 2007

N2 - The vulnerability or destabilization of atherosclerotic plaques has been directly linked to plaque composition. Imaging modalities, such as magnetic resonance (MR) imaging, that allow for evaluation of plaque composition at a cellular and molecular level, could further improve the detection of vulnerable plaque and may allow for monitoring the efficacy of antiatherosclerotic therapies. In this review we focus on MR imaging strategies for the detection and evaluation of atherosclerotic plaques and their composition. We highlight recent advancements in the development of MR pulse sequences, computer image analysis, and the use of commercially available MR contrast agents, such as gadopentic acid (Gd-DTPA), for plaque characterization. We also discuss molecular imaging strategies that are currently being used to design specific imaging probes targeted to biochemical and cellular markers of atherosclerotic plaque vulnerability

AB - The vulnerability or destabilization of atherosclerotic plaques has been directly linked to plaque composition. Imaging modalities, such as magnetic resonance (MR) imaging, that allow for evaluation of plaque composition at a cellular and molecular level, could further improve the detection of vulnerable plaque and may allow for monitoring the efficacy of antiatherosclerotic therapies. In this review we focus on MR imaging strategies for the detection and evaluation of atherosclerotic plaques and their composition. We highlight recent advancements in the development of MR pulse sequences, computer image analysis, and the use of commercially available MR contrast agents, such as gadopentic acid (Gd-DTPA), for plaque characterization. We also discuss molecular imaging strategies that are currently being used to design specific imaging probes targeted to biochemical and cellular markers of atherosclerotic plaque vulnerability

U2 - https://doi.org/10.1002/jmri.20989

DO - https://doi.org/10.1002/jmri.20989

M3 - Review article

C2 - 17729343

SN - 1053-1807

VL - 26

SP - 460

EP - 479

JO - Journal of magnetic resonance imaging

JF - Journal of magnetic resonance imaging

IS - 3

ER -