TY - JOUR
T1 - Magnetic resonance spectroscopy of in vivo tissue metabolism in small animals
AU - Prompers, Jeanine J.
AU - Strijkers, Gustav J.
AU - Nicolay, Klaas
PY - 2011
Y1 - 2011
N2 - In vivo magnetic resonance spectroscopy (MRS) allows for the non-invasive study of tissue metabolism. In this field, small animal models have greatly contributed to both technological advances and the development of applications to follow disease progression and response to treatments. The limited application of MRS in patients is primarily due to its relatively low sensitivity. With the developments of magnets with higher field strengths and hyperpolarized 13C-labeled substrates, it is expected that the impact of MRS technology in the study of tissue metabolism will grow in the coming years.
AB - In vivo magnetic resonance spectroscopy (MRS) allows for the non-invasive study of tissue metabolism. In this field, small animal models have greatly contributed to both technological advances and the development of applications to follow disease progression and response to treatments. The limited application of MRS in patients is primarily due to its relatively low sensitivity. With the developments of magnets with higher field strengths and hyperpolarized 13C-labeled substrates, it is expected that the impact of MRS technology in the study of tissue metabolism will grow in the coming years.
UR - http://www.scopus.com/inward/record.url?scp=84861226668&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ddtec.2011.11.009
DO - https://doi.org/10.1016/j.ddtec.2011.11.009
M3 - Review article
SN - 1740-6749
VL - 8
SP - e95-e102
JO - Drug Discovery Today: Technologies
JF - Drug Discovery Today: Technologies
IS - 2-4
ER -