TY - JOUR
T1 - Malignant mesothelioma after radiation treatment for Hodgkin lymphoma
AU - de Bruin, Marie L.
AU - Burgers, Jacobus A.
AU - Baas, Paul
AU - van 't Veer, Mars B.
AU - Noordijk, Evert M.
AU - Louwman, Marieke W. J.
AU - Zijlstra, Josée M.
AU - van den Berg, Hendrik
AU - Aleman, Berthe M. P.
AU - van Leeuwen, Flora E.
AU - Zijlstra-Baalbergen, J.M.
PY - 2009
Y1 - 2009
N2 - Malignant mesothelioma is a relatively uncommon malignancy. Although the pathogenesis is primarily related to asbestos, the disease may be associated with radiation exposure. Recently, increased risks for second primary mesothelioma after radiation for lymphoma have been reported. Because these findings are based on small numbers of patients, they need to be confirmed. We examined mesothelioma risk in 2567 5-year survivors of Hodgkin lymphoma. The risk was almost 30-fold increased in Hodgkin lymphoma patients treated with irradiation compared with the general population. Although histology and survival of the mesothelioma cases were comparable with cases from the general population, asbestos exposure and the proportion of males were lower than expected. The evidence for radiotherapy as cause for mesothelioma independent of exposure to asbestos is expanding, and the diagnosis of mesothelioma should be kept in mind whenever related symptoms arise in patients who had previous irradiation
AB - Malignant mesothelioma is a relatively uncommon malignancy. Although the pathogenesis is primarily related to asbestos, the disease may be associated with radiation exposure. Recently, increased risks for second primary mesothelioma after radiation for lymphoma have been reported. Because these findings are based on small numbers of patients, they need to be confirmed. We examined mesothelioma risk in 2567 5-year survivors of Hodgkin lymphoma. The risk was almost 30-fold increased in Hodgkin lymphoma patients treated with irradiation compared with the general population. Although histology and survival of the mesothelioma cases were comparable with cases from the general population, asbestos exposure and the proportion of males were lower than expected. The evidence for radiotherapy as cause for mesothelioma independent of exposure to asbestos is expanding, and the diagnosis of mesothelioma should be kept in mind whenever related symptoms arise in patients who had previous irradiation
U2 - https://doi.org/10.1182/blood-2008-10-184705
DO - https://doi.org/10.1182/blood-2008-10-184705
M3 - Article
C2 - 19234144
SN - 0006-4971
VL - 113
SP - 3679
EP - 3681
JO - Blood
JF - Blood
IS - 16
ER -