Management of Progressive Pulmonary Nodules Found during and outside of CT Lung Cancer Screening Studies

Mathias Meyer, Rozemarijn Vliegenthart, Thomas Henzler, Daniel Buergy, Frank A. Giordano, Michael Kostrzewa, Nils Rathmann, Odd Terje Brustugun, Lucio Crino, Anne Marie C. Dingemans, Michael Dusmet, Dean Fennell, Dominique Grunenwald, Rudolf Maria Huber, Marcin Moniuszko, Francoise Mornex, Mauro Papotti, Lothar Pilz, Suresh Senan, Kostas SyrigosMaurice Pérol, Jhanelle E. Gray, Christoph Schabel, Jan P. van Meerbeeck, Nico van Zandwijk, Cai Cun Zhou, Christian Manegold, Wieland Voigt, Eric Dominic Roessner

Research output: Contribution to journalReview articleAcademicpeer-review

8 Citations (Scopus)


Although the effectiveness of screening for lung cancer remains controversial, it is a fact that most lung cancers are diagnosed at an advanced stage outside of lung cancer screening programs. In 2013, the U.S. Preventive Services Task Force revised its lung cancer screening recommendation, now supporting lung cancer screening by low-dose computed tomography in patients at high risk. This is also endorsed by many major medical societies and advocacy group stakeholders, albeit with different eligibility criteria. In Europe, population-based lung cancer screening has so far not been recommended or implemented, as some important issues remain unresolved. Among them is the open question of how enlarging pulmonary nodules detected in lung cancer screening should be managed. This article comprises two parts: a review of the current lung cancer screening approaches and the potential therapeutic options for enlarging pulmonary nodules, followed by a meeting report including consensus statements of an interdisciplinary expert panel that discussed the potential of the different therapeutic options.

Original languageEnglish
Pages (from-to)1755-1765
Number of pages11
JournalJournal of thoracic oncology
Issue number12
Publication statusPublished - 1 Dec 2017


  • Lung cancer screening
  • Pulmonary nodules
  • Stereotactic ablative radiotherapy
  • Surgery

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