TY - JOUR
T1 - Manifesto for a European research network into obsessive-compulsive and related disorders
AU - Fineberg, N. A.
AU - Baldwin, D. S.
AU - Menchon, J. M.
AU - Denys, D.
AU - Grünblatt, E.
AU - Pallanti, S.
AU - Stein, D. J.
AU - Zohar, J.
AU - AUTHOR GROUP
AU - Alonso, Pino
AU - Andreewitch, Sergej
AU - Baldwin, David
AU - Bellodi, Laura
AU - Bersani, Giuseppe
AU - Cath, Danielle
AU - Chamberlain, Sam
AU - Clark, Luke
AU - Craig, Kevin
AU - dell'Osso, Bernardo
AU - Eilam, David
AU - Fineberg, Naomi
AU - Goudriaan Anna, E.
AU - Grünblatt, Edna
AU - Hermesh, Haggai
AU - Heyman, Isobel
AU - Hollander, Eric
AU - Hranov, Georgi
AU - Hranov, Luchezar
AU - Ivarsson, Tord
AU - Joel, Daphna
AU - Matthews, Keith
AU - Lochner, Christine
AU - Marazziti, Donatella
AU - Mataix-Cols, David
AU - Menchon, José
AU - Noldus, Lucas
AU - Pallanti, Stefano
AU - Robbins, Trevor
AU - Romanos, Marcel
AU - Renner, Tobias
AU - Rück, Christian
AU - Sahakian, Barbara
AU - Stein, Dan
AU - van den Brink, Wim
AU - van den Heuvel, Odile
AU - van der Wee, Nic
AU - Veltman, Dick
AU - Walitza, Susanne
AU - Zohar, Joseph
PY - 2013
Y1 - 2013
N2 - Obsessive-compulsive and related disorders (O-CRDs) are highly disabling psychiatric illnesses of early-onset. They are responsible for considerable morbidity and socioeconomic burden. Existing treatments are usually only partially successful and there is an urgent need to understand the aetiological factors and neurobiological bases of the disorders in order to develop new and more effective strategies for prevention, early detection and effective treatment. Emerging data from the neurosciences supports the reconceptualisation of obsessive-compulsive disorder as a spectrum disorder, related to but different from the anxiety disorders and closely aligned with other less well understood psychiatric disorders characterised by compulsive acts such as body dysmorphic disorder, trichotillomania, skin-picking disorder, hoarding disorder; and possibly extending to tic disorders and other neurodevelopmental disorders such as autism. A new, O-CRDs research network, supported by the Networks Initiative of the European College of Neuropsychopharmacology and comprising leading figures in preclinical and clinical research, has been established. It aims to provide a European perspective on the current debate around internationally-accepted diagnostic criteria and treatment strategies for O-CRDs. Its objectives include; (1) identifying the key outstanding research questions that depend upon cross-centre collaborative investigation, (2) setting a research agenda that is likely to produce an impact on health-outcomes, and (3) strengthening existing projects and collaborative enterprises with these objectives in mind. This paper reviews some of these critical research priorities. By establishing shared multinational databases, collaborative research networks, multicentre studies and joint publications, it is hoped that progress will be achieved
AB - Obsessive-compulsive and related disorders (O-CRDs) are highly disabling psychiatric illnesses of early-onset. They are responsible for considerable morbidity and socioeconomic burden. Existing treatments are usually only partially successful and there is an urgent need to understand the aetiological factors and neurobiological bases of the disorders in order to develop new and more effective strategies for prevention, early detection and effective treatment. Emerging data from the neurosciences supports the reconceptualisation of obsessive-compulsive disorder as a spectrum disorder, related to but different from the anxiety disorders and closely aligned with other less well understood psychiatric disorders characterised by compulsive acts such as body dysmorphic disorder, trichotillomania, skin-picking disorder, hoarding disorder; and possibly extending to tic disorders and other neurodevelopmental disorders such as autism. A new, O-CRDs research network, supported by the Networks Initiative of the European College of Neuropsychopharmacology and comprising leading figures in preclinical and clinical research, has been established. It aims to provide a European perspective on the current debate around internationally-accepted diagnostic criteria and treatment strategies for O-CRDs. Its objectives include; (1) identifying the key outstanding research questions that depend upon cross-centre collaborative investigation, (2) setting a research agenda that is likely to produce an impact on health-outcomes, and (3) strengthening existing projects and collaborative enterprises with these objectives in mind. This paper reviews some of these critical research priorities. By establishing shared multinational databases, collaborative research networks, multicentre studies and joint publications, it is hoped that progress will be achieved
U2 - https://doi.org/10.1016/j.euroneuro.2012.06.006
DO - https://doi.org/10.1016/j.euroneuro.2012.06.006
M3 - Article
C2 - 22796228
SN - 0924-977X
VL - 23
SP - 561
EP - 568
JO - European neuropsychopharmacology
JF - European neuropsychopharmacology
IS - 7
ER -