Mass Production and Size Control of Lipid-Polymer Hybrid Nanoparticles through Controlled Microvortices

Yongtae Kim; Bomy Lee Chung; Mingming Ma; Willem J. M. Mulder; Zahi A. Fayad; Omid C. Farokhzad; Robert Langer

doi:https://doi.org/10.1021/nl301253v

Mass Production and Size Control of Lipid-Polymer Hybrid Nanoparticles through Controlled Microvortices

Yongtae Kim, Bomy Lee Chung, Mingming Ma, Willem J. M. Mulder, Zahi A. Fayad, Omid C. Farokhzad, Robert Langer

Research output: Contribution to journal › Article › Academic › peer-review

199 Citations (Scopus)

Abstract

Lipid-polymer hybrid (LPH) nanoparticles can deliver a wide range of therapeutic compounds in a controlled manner. LPH nanoparticle syntheses using microfluidics improve the mixing process but are restricted by a low throughput. In this study, we present a pattern-tunable microvortex platform that allows mass production and size control of LPH nanoparticles with superior reproducibility and homogeneity. We demonstrate that by varying flow rates (i.e., Reynolds number (30-150)) we can control the nanoparticle size (30-170 nm) with high productivity (∼3 g/hour) and low polydispersity (∼0.1). Our approach may contribute to efficient development and optimization of a wide range of multicomponent nanoparticles for medical imaging and drug delivery

Original language	English
Pages (from-to)	3587-3591
Journal	Nano letters
Volume	12
Issue number	7
DOIs	https://doi.org/10.1021/nl301253v
Publication status	Published - 2012

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https://doi.org/10.1021/nl301253v

Cite this

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title = "Mass Production and Size Control of Lipid-Polymer Hybrid Nanoparticles through Controlled Microvortices",

abstract = "Lipid-polymer hybrid (LPH) nanoparticles can deliver a wide range of therapeutic compounds in a controlled manner. LPH nanoparticle syntheses using microfluidics improve the mixing process but are restricted by a low throughput. In this study, we present a pattern-tunable microvortex platform that allows mass production and size control of LPH nanoparticles with superior reproducibility and homogeneity. We demonstrate that by varying flow rates (i.e., Reynolds number (30-150)) we can control the nanoparticle size (30-170 nm) with high productivity (∼3 g/hour) and low polydispersity (∼0.1). Our approach may contribute to efficient development and optimization of a wide range of multicomponent nanoparticles for medical imaging and drug delivery",

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T1 - Mass Production and Size Control of Lipid-Polymer Hybrid Nanoparticles through Controlled Microvortices

AU - Kim, Yongtae

AU - Lee Chung, Bomy

AU - Ma, Mingming

AU - Mulder, Willem J. M.

AU - Fayad, Zahi A.

AU - Farokhzad, Omid C.

AU - Langer, Robert

PY - 2012

Y1 - 2012

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AB - Lipid-polymer hybrid (LPH) nanoparticles can deliver a wide range of therapeutic compounds in a controlled manner. LPH nanoparticle syntheses using microfluidics improve the mixing process but are restricted by a low throughput. In this study, we present a pattern-tunable microvortex platform that allows mass production and size control of LPH nanoparticles with superior reproducibility and homogeneity. We demonstrate that by varying flow rates (i.e., Reynolds number (30-150)) we can control the nanoparticle size (30-170 nm) with high productivity (∼3 g/hour) and low polydispersity (∼0.1). Our approach may contribute to efficient development and optimization of a wide range of multicomponent nanoparticles for medical imaging and drug delivery

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DO - https://doi.org/10.1021/nl301253v

M3 - Article

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SN - 1530-6984

VL - 12

SP - 3587

EP - 3591

JO - Nano letters

JF - Nano letters

IS - 7

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