Measurement of left ventricular volumes and function with O-15-labeled carbon monoxide gated positron emission tomography: Comparison with magnetic resonance imaging

Hadassa A. Hofman, Paul Knaapen, Ronald Boellaard, Olga Bondarenko, Marco J.W. Götte, Willem G. van Dockum, Cees A. Visser, Albert C. van Rossum, Adriaan A. Lammertsma, Frans C. Visser

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Background. Positron emission tomography (PET) with inhaled oxygen 15-labeled carbon monoxide (CO) is used as a marker of myocardial blood pool. Only a limited number of studies with small numbers of patients have reported on the assessment of left ventricular (LV) volumes by use of O-15-labeled CO. The aim of this study was to compare LV volumes and function as measured by routinely acquired blood pool images by use of gated O-15-labeled CO PET with the reference technique, cardiovascular magnetic resonance imaging (MRI). Methods and results. Thirty-four subjects with a varying degree of LV function were studied. LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), and LV ejection fraction (LVEF) were determined by both MRI and gated PET by use of O-15-labeled CO. Volumes were comparable with respect to LVEDV (196 ± 83 and 192 ± 91 mL, respectively; P = not significant). LVESV, however, was slightly overestimated by PET (119 ± 85 and 136 ± 94 mL, respectively; P < .05), resulting in a significant underestimation of LVEF (44% ± 19% and 35% ± 18%, respectively; P < .05). Observed correlations for LVEDV, LVESV, and LVEF were 0.90, 0.96, and 0.86, respectively (all P< .01). Conclusions. Gated O-15-labeled CO PET measurements of LVEDV, LVESV, and LVEF show good correlation with MRI over a wide range of LV volumes during routinely acquired blood pool images. LVEF, however, may be underestimated compared with MRI.

Original languageEnglish
Pages (from-to)639-644
Number of pages6
JournalJournal of Nuclear Cardiology
Issue number6
Publication statusPublished - 1 Nov 2005


  • Gated oxygen 15-labeled carbon monoxide positron emission tomography
  • Left ventricular ejection fraction
  • Left ventricular volumes
  • Magnetic resonance imaging

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