TY - JOUR
T1 - Measurement of Salivary Pepsin to Detect Gastroesophageal Reflux Disease Is Not Ready for Clinical Application
AU - Woodland, Philip
AU - Singendonk, Maartje M. J.
AU - Ooi, Joanne
AU - Nikaki, Kornilia
AU - Wong, Terry
AU - Lee, Chung
AU - Glasinovic, Esteban
AU - Koning, Romy
AU - Lutter, Rene
AU - Benninga, Marc A.
AU - van Wijk, Michiel P.
AU - Sifrim, Daniel
PY - 2019/2/1
Y1 - 2019/2/1
N2 - A noninvasive test for gastroesophageal reflux disease (GERD) is desirable for adults and children. Salivary pepsin measurement has been proposed as such a test.1–3 A previous study from our group demonstrated that a maximal salivary pepsin cutoff of >210 ng/mL using the PepTest device (RD Biomed, Hull, United Kingdom) had excellent specificity of 96% but modest sensitivity of 44% to diagnose GERD,4 leading to optimism about its potential use. In this study, we aimed to confirm the previously reported sensitivity and specificity in healthy volunteers and patients with heartburn, evaluate the association between a positive PepTest and response to proton pump inhibitor (PPI) therapy, assess if test-sensitivity can be improved for GERD when samples are taken over a 72-hour sampling period, and establish normal values of salivary pepsin in infants.
AB - A noninvasive test for gastroesophageal reflux disease (GERD) is desirable for adults and children. Salivary pepsin measurement has been proposed as such a test.1–3 A previous study from our group demonstrated that a maximal salivary pepsin cutoff of >210 ng/mL using the PepTest device (RD Biomed, Hull, United Kingdom) had excellent specificity of 96% but modest sensitivity of 44% to diagnose GERD,4 leading to optimism about its potential use. In this study, we aimed to confirm the previously reported sensitivity and specificity in healthy volunteers and patients with heartburn, evaluate the association between a positive PepTest and response to proton pump inhibitor (PPI) therapy, assess if test-sensitivity can be improved for GERD when samples are taken over a 72-hour sampling period, and establish normal values of salivary pepsin in infants.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060299151&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29782998
U2 - https://doi.org/10.1016/j.cgh.2018.05.016
DO - https://doi.org/10.1016/j.cgh.2018.05.016
M3 - Article
C2 - 29782998
SN - 1542-3565
VL - 17
SP - 563
EP - 565
JO - Clinical Gastroenterology and Hepatology
JF - Clinical Gastroenterology and Hepatology
IS - 3
ER -