TY - JOUR
T1 - Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases
T2 - a position paper by the ESC Working Group on Coronary Pathophysiology and Microcirculation
AU - Tousoulis, Dimitris
AU - Guzik, Tomasz
AU - Padro, Teresa
AU - Duncker, Dirk J.
AU - de Luca, Giuseppe
AU - Eringa, Etto
AU - Vavlukis, Marija
AU - Antonopoulos, Alexios S.
AU - Katsimichas, Themistoklis
AU - Cenko, Edina
AU - Djordjevic-Dikic, Ana
AU - Fleming, Ingrid
AU - Manfrini, Olivia
AU - Trifunovic, Danijela
AU - Antoniades, Charalambos
AU - Crea, Filippo
PY - 2022/12/29
Y1 - 2022/12/29
N2 - The human gut microbiota is the microbial ecosystem in the small and large intestines of humans. It has been naturally preserved and evolved to play an important role in the function of the gastrointestinal tract and the physiology of its host, protecting from pathogen colonization, and participating in vitamin synthesis, the functions of the immune system, as well as glucose homeostasis and lipid metabolism, among others. Mounting evidence from animal and human studies indicates that the composition and metabolic profiles of the gut microbiota are linked to the pathogenesis of cardiovascular disease, particularly arterial hypertension, atherosclerosis, and heart failure. In this review article, we provide an overview of the function of the human gut microbiota, summarize, and critically address the evidence linking compositional and functional alterations of the gut microbiota with atherosclerosis and coronary artery disease and discuss the potential of strategies for therapeutically targeting the gut microbiota through various interventions.
AB - The human gut microbiota is the microbial ecosystem in the small and large intestines of humans. It has been naturally preserved and evolved to play an important role in the function of the gastrointestinal tract and the physiology of its host, protecting from pathogen colonization, and participating in vitamin synthesis, the functions of the immune system, as well as glucose homeostasis and lipid metabolism, among others. Mounting evidence from animal and human studies indicates that the composition and metabolic profiles of the gut microbiota are linked to the pathogenesis of cardiovascular disease, particularly arterial hypertension, atherosclerosis, and heart failure. In this review article, we provide an overview of the function of the human gut microbiota, summarize, and critically address the evidence linking compositional and functional alterations of the gut microbiota with atherosclerosis and coronary artery disease and discuss the potential of strategies for therapeutically targeting the gut microbiota through various interventions.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85139743505&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/35420126
U2 - https://doi.org/10.1093/cvr/cvac057
DO - https://doi.org/10.1093/cvr/cvac057
M3 - Review article
C2 - 35420126
SN - 0008-6363
VL - 118
SP - 3171
EP - 3182
JO - Cardiovascular research
JF - Cardiovascular research
IS - 16
ER -