TY - JOUR
T1 - Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue
AU - Saxton, Sophie N.
AU - Clark, Ben J.
AU - Withers, Sarah B.
AU - Eringa, Etto C.
AU - Heagerty, Anthony M.
PY - 2019
Y1 - 2019
N2 - Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be the inflammatory cell population in adipose tissue. Healthy adipose tissue secretes a number of vasoactive adipokines and anti-inflammatory cytokines, and changes to this secretory profile will contribute to pathogenesis in obesity. In this review, we discuss the links between adipokine dysregulation and the development of hypertension and diabetes and explore the potential for manipulating adipose tissue morphology and its immune cell population to improve cardiovascular health in obesity.
AB - Obesity is increasingly prevalent and is associated with substantial cardiovascular risk. Adipose tissue distribution and morphology play a key role in determining the degree of adverse effects, and a key factor in the disease process appears to be the inflammatory cell population in adipose tissue. Healthy adipose tissue secretes a number of vasoactive adipokines and anti-inflammatory cytokines, and changes to this secretory profile will contribute to pathogenesis in obesity. In this review, we discuss the links between adipokine dysregulation and the development of hypertension and diabetes and explore the potential for manipulating adipose tissue morphology and its immune cell population to improve cardiovascular health in obesity.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85070474105&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/31339053
U2 - https://doi.org/10.1152/physrev.00034.2018
DO - https://doi.org/10.1152/physrev.00034.2018
M3 - Review article
C2 - 31339053
SN - 0031-9333
VL - 99
SP - 1701
EP - 1763
JO - Physiological Reviews
JF - Physiological Reviews
IS - 4
ER -