Medicijngeïnduceerde huidpigmentaties

The use of various types of medication can lead to pigment disorders of the skin. Blue-grey discoloration is the most frequent skin problem encountered when using specific drugs. Antibiotics, cytostatics and antipsychotics are the group of drugs most commonly associated with pigmention side effects. There are however numerous case reports of drugs that result in dyspigmentation on the skin, but causal relation and method of action are usually poorly investigated. Not only systemic therapies, but also topical treatments can result in dyspigmentation. The use of hydrochi-non containing creams, a well-known and frequently used bleaching agent, can not only result in hypopigmentation, but also hyperpigmentation. New, so called, “targeted therapies” can also affect the pigmentation and “immune checkpoint blockers” can induce depigmentation of the skin clinically indistinguishable from vitiligo. In dark skinned persons, drug reactions will frequently present themselves with (post-inflammatory) hyperpigmentation, but this should not be considered as a true drug induced pigment disorder. Cessation of use of the inducer of the pigment disorder will not always result in normalization of the pigment disorder.