TY - JOUR
T1 - Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium
AU - EYE-RISK Consortium
AU - Merle, B. nédicte M. J.
AU - Colijn, Johanna M.
AU - Cougnard-Grégoire, Audrey
AU - de Koning-Backus, Alexandra P. M.
AU - Delyfer, Marie-Noëlle
AU - Kiefte-de Jong, Jessica C.
AU - Meester-Smoor, Magda
AU - Féart, Catherine
AU - Verzijden, Timo
AU - Samieri, C. cilia
AU - Franco, Oscar H.
AU - Korobelnik, Jean-François
AU - Klaver, Caroline C. W.
AU - Delcourt, C. cile
AU - Ajana, Soufiane
AU - Arango-Gonzalez, Blanca
AU - Armento, Angela
AU - Arndt, Verena
AU - Bhatia, Vaibhav
AU - Bhattacharya, Shomi S.
AU - Biarnés, Marc
AU - Borrell, Anna
AU - Bühren, Sebastian
AU - Calado, Sofia M.
AU - Colijn, Johanna M.
AU - Cougnard-Grégoire, Audrey
AU - Dammeier, Sascha
AU - de Jong, Eiko K.
AU - de la Cerda, Berta
AU - Delcourt, C. cile
AU - den Hollander, Anneke I.
AU - Diaz-Corrales, Francisco J.
AU - Diether, Sigrid
AU - Emri, Eszter
AU - Endermann, Tanja
AU - Ferraro, Lucia L.
AU - Garcia, M. riam
AU - Heesterbeek, Thomas J.
AU - Honisch, Sabina
AU - Hoyng, Carel B.
AU - Kersten, Eveline
AU - Kilger, Ellen
AU - Klaver, Caroline C. W.
AU - Langen, Hanno
AU - Lengyel, Imre
AU - Luthert, Phil
AU - Maugeais, Cyrille
AU - Meester-Smoor, Magda
AU - van Leeuwen, Elisabeth M.
AU - van Leeuwen, Elisabeth M.
N1 - Funding Information: At baseline, 7983 eligible persons 55 years of age or older were interviewed and examined. Ophthalmologic examinations were carried out and fundus photographs were obtained at each round starting from 1990 through 1993. Follow-up rounds were completed from 1993 through 1995, from 1997 through 1999, from 2002 through 2004, and from 2009 through 2011. After pharmacologic mydriasis, 35° stereoscopic color fundus photographs of the macula (Topcon TRV-50VT; Topcon Optical Co., Tokyo, Japan) were obtained in each of the first 3 visits, and 35° digital images (Topcon TRC 50EX) were obtained for the fourth and fifth visits. 31 The Rotterdam Study was approved by the Medical Ethics Committee of the Erasmus Medical Center (registration number, MEC 02.1015) and by the Dutch Ministry of Health, Welfare and Sport (Population Screening Act WBO; license number, 1071272-159521-PG). The Rotterdam Study has been entered into the Netherlands National Trial Register ( www.trialregister.nl ) and into the World Health Organization International Clinical Trials Registry Platform ( www.who.int/ictrp/network/primary/en/ ) under shared catalog number NTR6831. Publisher Copyright: © 2018 American Academy of Ophthalmology Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Purpose: To investigate associations of adherence to the Mediterranean diet (MeDi) with incidence of advanced age-related macular degeneration (AMD; the symptomatic form of AMD) in 2 European population-based prospective cohorts. Design: Prospective cohort study of the Rotterdam Study I (RS-I) and the Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires (Alienor) Study populations. Participants: Four thousand four hundred forty-six participants 55 years of age or older from the RS-I (The Netherlands) and 550 French adults 73 years of age or older from the Alienor Study with complete ophthalmologic and dietary data were included in the present study. Methods: Examinations were performed approximately every 5 years over a 21-year period (1990–2011) in RS-I and every 2 years over a 4-year period (2006–2012) in the Alienor Study. Adherence to the MeDi was evaluated using a 9-component score based on intake of vegetables, fruits, legumes, cereals, fish, meat, dairy products, alcohol, and the monounsaturated-to-saturated fatty acids ratio. Associations of incidence of AMD with MeDi were estimated using multivariate Cox proportional hazard models. Main Outcomes Measures: Incidence of advanced AMD based on retinal fundus photographs. Results: Among the 4996 included participants, 155 demonstrated advanced incident AMD (117 from the RS-I and 38 from the Alienor Study). The mean follow-up time was 9.9 years (range, 0.6–21.7 years) in the RS-I and 4.1 years (range, 2.5–5.0 years) in the Alienor Study. Pooling data for both the RS-I and Alienor Study, participants with a high (range, 6–9) MeDi score showed a significantly reduced risk for incident advanced AMD compared with participants with a low (range, 0–3) MeDi score in the fully adjusted Cox model (hazard ratio, 0.59; 95% confidence interval, 0.37–0.95; P = 0.04 for trend). Conclusions: Pooling data from the RS-I and Alienor Study, higher adherence to the MeDi was associated with a 41% reduced risk of incident advanced AMD. These findings support the role of a diet rich in healthful nutrient-rich foods such as fruits, vegetables, legumes, and fish in the prevention of AMD.
AB - Purpose: To investigate associations of adherence to the Mediterranean diet (MeDi) with incidence of advanced age-related macular degeneration (AMD; the symptomatic form of AMD) in 2 European population-based prospective cohorts. Design: Prospective cohort study of the Rotterdam Study I (RS-I) and the Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires (Alienor) Study populations. Participants: Four thousand four hundred forty-six participants 55 years of age or older from the RS-I (The Netherlands) and 550 French adults 73 years of age or older from the Alienor Study with complete ophthalmologic and dietary data were included in the present study. Methods: Examinations were performed approximately every 5 years over a 21-year period (1990–2011) in RS-I and every 2 years over a 4-year period (2006–2012) in the Alienor Study. Adherence to the MeDi was evaluated using a 9-component score based on intake of vegetables, fruits, legumes, cereals, fish, meat, dairy products, alcohol, and the monounsaturated-to-saturated fatty acids ratio. Associations of incidence of AMD with MeDi were estimated using multivariate Cox proportional hazard models. Main Outcomes Measures: Incidence of advanced AMD based on retinal fundus photographs. Results: Among the 4996 included participants, 155 demonstrated advanced incident AMD (117 from the RS-I and 38 from the Alienor Study). The mean follow-up time was 9.9 years (range, 0.6–21.7 years) in the RS-I and 4.1 years (range, 2.5–5.0 years) in the Alienor Study. Pooling data for both the RS-I and Alienor Study, participants with a high (range, 6–9) MeDi score showed a significantly reduced risk for incident advanced AMD compared with participants with a low (range, 0–3) MeDi score in the fully adjusted Cox model (hazard ratio, 0.59; 95% confidence interval, 0.37–0.95; P = 0.04 for trend). Conclusions: Pooling data from the RS-I and Alienor Study, higher adherence to the MeDi was associated with a 41% reduced risk of incident advanced AMD. These findings support the role of a diet rich in healthful nutrient-rich foods such as fruits, vegetables, legumes, and fish in the prevention of AMD.
UR - http://www.scopus.com/inward/record.url?scp=85053669205&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ophtha.2018.08.006
DO - https://doi.org/10.1016/j.ophtha.2018.08.006
M3 - Article
C2 - 30114418
SN - 0161-6420
VL - 126
SP - 381
EP - 390
JO - Ophthalmology
JF - Ophthalmology
IS - 3
ER -