MEIS and PBX homeobox proteins in ovarian cancer

A P G Crijns; P de Graeff; D Geerts; K A Ten Hoor; H Hollema; T van der Sluis; R M W Hofstra; G H de Bock; S de Jong; A G J van der Zee; E G E de Vries

doi:https://doi.org/10.1016/j.ejca.2007.08.025

MEIS and PBX homeobox proteins in ovarian cancer

A P G Crijns, P de Graeff, D Geerts, K A Ten Hoor, H Hollema, T van der Sluis, R M W Hofstra, G H de Bock, S de Jong, A G J van der Zee, E G E de Vries

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Three amino-acid loop extension (TALE) homeobox proteins MEIS and PBX are cofactors for HOX-class homeobox proteins, which control growth and differentiation during embryogenesis and homeostasis. We showed that MEIS and PBX expression are related to cisplatin resistance in ovarian cancer cell lines. Therefore, MEIS1, MEIS2 and PBX expression were investigated immunohistochemically in a tissue microarray (N=232) of ovarian cancers and ovarian surface epithelium (N=15). Results were related to clinicopathologic characteristics and survival. All cancers expressed MEIS1, MEIS2 and PBX in nucleus and cytoplasm. MEIS1 and 2 only stained nuclear in surface epithelium. Nuclear MEIS2 was negatively related to stage, grade and overall survival in univariate analyses. Additionally, MEIS and PBX RNA expression in ovarian surface epithelium and other normal tissues and ovarian cancer versus other tumour types using public array data sets were studied. In ovarian cancer, MEIS1 is highly expressed compared to other cancer types. In conclusion, MEIS and PBX are extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis.

Original language	English
Pages (from-to)	2495-505
Number of pages	11
Journal	European Journal of Cancer
Volume	43
Issue number	17
DOIs	https://doi.org/10.1016/j.ejca.2007.08.025
Publication status	Published - Nov 2007

Keywords

Adult
Aged
Aged, 80 and over
Female
Homeodomain Proteins/metabolism
Humans
Immunohistochemistry
Middle Aged
Myeloid Ecotropic Viral Integration Site 1 Protein
Neoplasm Proteins/metabolism
Ovarian Neoplasms/metabolism
Transcription Factors/metabolism

Access to Document

https://doi.org/10.1016/j.ejca.2007.08.025

Cite this

@article{63a441f8371448728197a1ab6e3b5ca1,

title = "MEIS and PBX homeobox proteins in ovarian cancer",

abstract = "Three amino-acid loop extension (TALE) homeobox proteins MEIS and PBX are cofactors for HOX-class homeobox proteins, which control growth and differentiation during embryogenesis and homeostasis. We showed that MEIS and PBX expression are related to cisplatin resistance in ovarian cancer cell lines. Therefore, MEIS1, MEIS2 and PBX expression were investigated immunohistochemically in a tissue microarray (N=232) of ovarian cancers and ovarian surface epithelium (N=15). Results were related to clinicopathologic characteristics and survival. All cancers expressed MEIS1, MEIS2 and PBX in nucleus and cytoplasm. MEIS1 and 2 only stained nuclear in surface epithelium. Nuclear MEIS2 was negatively related to stage, grade and overall survival in univariate analyses. Additionally, MEIS and PBX RNA expression in ovarian surface epithelium and other normal tissues and ovarian cancer versus other tumour types using public array data sets were studied. In ovarian cancer, MEIS1 is highly expressed compared to other cancer types. In conclusion, MEIS and PBX are extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis.",

keywords = "Adult, Aged, Aged, 80 and over, Female, Homeodomain Proteins/metabolism, Humans, Immunohistochemistry, Middle Aged, Myeloid Ecotropic Viral Integration Site 1 Protein, Neoplasm Proteins/metabolism, Ovarian Neoplasms/metabolism, Transcription Factors/metabolism",

author = "Crijns, {A P G} and {de Graeff}, P and D Geerts and {Ten Hoor}, {K A} and H Hollema and {van der Sluis}, T and Hofstra, {R M W} and {de Bock}, {G H} and {de Jong}, S and {van der Zee}, {A G J} and {de Vries}, {E G E}",

year = "2007",

month = nov,

doi = "https://doi.org/10.1016/j.ejca.2007.08.025",

language = "English",

volume = "43",

pages = "2495--505",

journal = "European Journal of Cancer",

issn = "0959-8049",

publisher = "Elsevier Limited",

number = "17",

}

TY - JOUR

T1 - MEIS and PBX homeobox proteins in ovarian cancer

AU - Crijns, A P G

AU - de Graeff, P

AU - Geerts, D

AU - Ten Hoor, K A

AU - Hollema, H

AU - van der Sluis, T

AU - Hofstra, R M W

AU - de Bock, G H

AU - de Jong, S

AU - van der Zee, A G J

AU - de Vries, E G E

PY - 2007/11

Y1 - 2007/11

N2 - Three amino-acid loop extension (TALE) homeobox proteins MEIS and PBX are cofactors for HOX-class homeobox proteins, which control growth and differentiation during embryogenesis and homeostasis. We showed that MEIS and PBX expression are related to cisplatin resistance in ovarian cancer cell lines. Therefore, MEIS1, MEIS2 and PBX expression were investigated immunohistochemically in a tissue microarray (N=232) of ovarian cancers and ovarian surface epithelium (N=15). Results were related to clinicopathologic characteristics and survival. All cancers expressed MEIS1, MEIS2 and PBX in nucleus and cytoplasm. MEIS1 and 2 only stained nuclear in surface epithelium. Nuclear MEIS2 was negatively related to stage, grade and overall survival in univariate analyses. Additionally, MEIS and PBX RNA expression in ovarian surface epithelium and other normal tissues and ovarian cancer versus other tumour types using public array data sets were studied. In ovarian cancer, MEIS1 is highly expressed compared to other cancer types. In conclusion, MEIS and PBX are extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis.

AB - Three amino-acid loop extension (TALE) homeobox proteins MEIS and PBX are cofactors for HOX-class homeobox proteins, which control growth and differentiation during embryogenesis and homeostasis. We showed that MEIS and PBX expression are related to cisplatin resistance in ovarian cancer cell lines. Therefore, MEIS1, MEIS2 and PBX expression were investigated immunohistochemically in a tissue microarray (N=232) of ovarian cancers and ovarian surface epithelium (N=15). Results were related to clinicopathologic characteristics and survival. All cancers expressed MEIS1, MEIS2 and PBX in nucleus and cytoplasm. MEIS1 and 2 only stained nuclear in surface epithelium. Nuclear MEIS2 was negatively related to stage, grade and overall survival in univariate analyses. Additionally, MEIS and PBX RNA expression in ovarian surface epithelium and other normal tissues and ovarian cancer versus other tumour types using public array data sets were studied. In ovarian cancer, MEIS1 is highly expressed compared to other cancer types. In conclusion, MEIS and PBX are extensively expressed in ovarian carcinomas and may play a role in ovarian carcinogenesis.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Female

KW - Homeodomain Proteins/metabolism

KW - Humans

KW - Immunohistochemistry

KW - Middle Aged

KW - Myeloid Ecotropic Viral Integration Site 1 Protein

KW - Neoplasm Proteins/metabolism

KW - Ovarian Neoplasms/metabolism

KW - Transcription Factors/metabolism

U2 - https://doi.org/10.1016/j.ejca.2007.08.025

DO - https://doi.org/10.1016/j.ejca.2007.08.025

M3 - Article

C2 - 17949970

SN - 0959-8049

VL - 43

SP - 2495

EP - 2505

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 17

ER -