TY - JOUR
T1 - Melanocyte-specific immune response in melanoma and vitiligo: two faces of the same coin?
AU - Wankowicz-Kalinska, Anna
AU - Le Poole, Caroline
AU - van den Wijngaard, Rene
AU - Storkus, Walter J.
AU - Das, Pranab K.
PY - 2003
Y1 - 2003
N2 - The appearance of depigmentation during the course of malignant melanoma has been considered a good prognostic sign. Is it only a side-effect, informative of the immune system's response to the treatment, or does it act as a necessary amplifier of these clinically important anti-tumor responses? The current review will attempt to tackle this question by reviewing the current literature, as well as by posing some novel hypotheses. Understanding the nature of humoral and cellular immune responses directed against normal melanocytes and their malignant counterparts may lead to the design of improved therapeutic strategies relevant to both vitiligo and melanoma
AB - The appearance of depigmentation during the course of malignant melanoma has been considered a good prognostic sign. Is it only a side-effect, informative of the immune system's response to the treatment, or does it act as a necessary amplifier of these clinically important anti-tumor responses? The current review will attempt to tackle this question by reviewing the current literature, as well as by posing some novel hypotheses. Understanding the nature of humoral and cellular immune responses directed against normal melanocytes and their malignant counterparts may lead to the design of improved therapeutic strategies relevant to both vitiligo and melanoma
U2 - https://doi.org/10.1034/j.1600-0749.2003.00038.x
DO - https://doi.org/10.1034/j.1600-0749.2003.00038.x
M3 - Article
C2 - 12753398
SN - 0893-5785
VL - 16
SP - 254
EP - 260
JO - Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society
JF - Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society
IS - 3
ER -