Melatonine: fysiologische en pathofysiologische aspecten en mogelijke toepassingen

Translated title of the contribution: Melatonin: physiological and pathophysiological aspects and possible applications

M J de Graaff, R M Buijs, J B L Hoekstra, E Fliers, F Holleman

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The number of indications for the medical use of melatonin is slowly increasing. Melatonin is produced by the pineal gland and is a key signal in the circadian rhythm of the body. Melatonin plays an obvious role in the pathophysiology and treatment of sleep disorders and jetlag. Recent research has also demonstrated its favourable effect on blood-pressure regulation. By analogy, melatonin may play a role in a variety of other circadian processes. However, research into the precise effects is still insufficient.

Translated title of the contributionMelatonin: physiological and pathophysiological aspects and possible applications
Original languageDutch
Pages (from-to)1971-5
Number of pages5
JournalNederlands Tijdschrift voor Geneeskunde
Volume150
Issue number36
Publication statusPublished - 9 Sept 2006

Keywords

  • Blood Pressure/physiology
  • Circadian Rhythm/physiology
  • Humans
  • Melatonin/physiology
  • Pineal Gland/physiology
  • Sleep Wake Disorders/drug therapy
  • Travel

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