TY - JOUR
T1 - Metabolic syndrome and cognition in patients with manifest atherosclerotic disease
T2 - The SMART study
AU - Muller, Majon
AU - van Raamt, Fleur
AU - Visseren, Frank L. J.
AU - Kalmijn, Sandra
AU - Geerlings, Mirjam I.
AU - Mali, Willem P. T. M.
AU - van der Graaf, Yolanda
AU - Muller, T.H.
AU - Galis-de Graaf, Y.
PY - 2010/2
Y1 - 2010/2
N2 - Background: It is unclear whether the metabolic syndrome (MetS) increases risk of cognitive dysfunction beyond the level expected from its individual components. We examined the association of MetS with cognitive dysfunction and assessed whether MetS increased risk of cognitive dysfunction more than that of the sum of its individual components. Methods: Data on 823 participants were used from the SMART-study, a cohort study among patients with atherosclerotic disease. MetS was defined according to the NCEP-ATPIII-criteria. Neuropsychological tests assessing memory, executive, and visuospatial functioning were performed. Regression analyses were performed to assess the association of MetS and its individual components with cognitive dysfunction. To examine whether MetS increased risk of cognitive dysfunction beyond its individual components we tested whether there was interaction on an additive scale by calculating the relative excess risk due to interaction (RERI). Results: MetS was associated with increased risk of memory (OR 2.0, 95% CI 1.1-3.3) and visuospatial dysfunction (OR 2.3, 95% CI 1.4-2.7) but not with executive dysfunction. However, risk of memory and visuospatial dysfunction for having all MetS components was not greater than that of the sum of the individual components (RERI 0.2 and -0.9). Conclusions: In this population, MetS is related to increased risk of cognitive dysfunction but not more than that of the sum of its individual components. Copyright © 2009 S. Karger AG.
AB - Background: It is unclear whether the metabolic syndrome (MetS) increases risk of cognitive dysfunction beyond the level expected from its individual components. We examined the association of MetS with cognitive dysfunction and assessed whether MetS increased risk of cognitive dysfunction more than that of the sum of its individual components. Methods: Data on 823 participants were used from the SMART-study, a cohort study among patients with atherosclerotic disease. MetS was defined according to the NCEP-ATPIII-criteria. Neuropsychological tests assessing memory, executive, and visuospatial functioning were performed. Regression analyses were performed to assess the association of MetS and its individual components with cognitive dysfunction. To examine whether MetS increased risk of cognitive dysfunction beyond its individual components we tested whether there was interaction on an additive scale by calculating the relative excess risk due to interaction (RERI). Results: MetS was associated with increased risk of memory (OR 2.0, 95% CI 1.1-3.3) and visuospatial dysfunction (OR 2.3, 95% CI 1.4-2.7) but not with executive dysfunction. However, risk of memory and visuospatial dysfunction for having all MetS components was not greater than that of the sum of the individual components (RERI 0.2 and -0.9). Conclusions: In this population, MetS is related to increased risk of cognitive dysfunction but not more than that of the sum of its individual components. Copyright © 2009 S. Karger AG.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=72049129177&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/20016217
U2 - https://doi.org/10.1159/000264825
DO - https://doi.org/10.1159/000264825
M3 - Article
C2 - 20016217
SN - 0251-5350
VL - 34
SP - 83
EP - 89
JO - Neuroepidemiology
JF - Neuroepidemiology
IS - 2
ER -