TY - JOUR
T1 - Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls
T2 - A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls
AU - Bot, M
AU - Milaneschi, Y
AU - Al-Shehri, T
AU - Amin, N
AU - Garmaeva, S
AU - Onderwater, GLJ
AU - Pool, R
AU - Thesing, CS
AU - Vijfhuizen, LS
AU - Vogelzangs, N
AU - Arts, ICW
AU - Demirkan, A
AU - van Duijn, C
AU - van Greevenbroek, M
AU - van der Kallen, CJH
AU - Köhler, S
AU - Ligthart, L
AU - van den Maagdenberg, AMJM
AU - Mook-Kanamori, DO
AU - de Mutsert, R
AU - Tiemeier, H
AU - Schram, MT
AU - Stehouwer, CDA
AU - Terwindt, GM
AU - Willems van Dijk, K
AU - Fu, J
AU - Zhernakova, A
AU - Beekman, M
AU - Slagboom, PE
AU - Boomsma, DI
AU - Penninx, BWJH
AU - Beekman, M
AU - Suchiman, HED
AU - Deelen, J
AU - Amin, N
AU - Beulens, JW
AU - van der Bom, JA
AU - Bomer, N
AU - Demirkan, A
AU - van Hilten, JA
AU - Meessen, JMTA
AU - Pool, R
AU - Moed, MH
AU - Fu, J
AU - Rutters, F
AU - So-Osman, C
AU - van der Flier, WM
AU - van der Heijden, AAWA
AU - van der Spek, A
AU - Asselbergs, FW
AU - Boersma, E
AU - Elders, PM
AU - Geleijnse, JM
AU - Ikram, MA
AU - Kloppenburg, M
AU - Meulenbelt, I
AU - Mooijaart, SP
AU - Nelissen, RGHH
AU - Netea, MG
AU - Penninx, BWJH
AU - Stehouwer, CDA
AU - Teunissen, CE
AU - Terwindt, GM
AU - ’t Hart, LM
AU - van den Maagdenberg, AMJM
AU - van der Harst, P
AU - van der Horst, ICC
AU - van Greevenbroek, MMJ
AU - van Spil, WE
AU - Wijmenga, C
AU - Zwinderman, AH
AU - Zhernikova, A
AU - Jukema, JW
AU - Sattar, N
AU - BBMRI-NL Metabolomics Consortium
AU - van der Kallen, Carla J.H.
AU - van den Maagdenberg, Arn M.J.M.
AU - Mook-Kanamori, Dennis O.
AU - Schram, Miranda T.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Background: Depression has been associated with metabolic alterations, which adversely impact cardiometabolic health. Here, a comprehensive set of metabolic markers, predominantly lipids, was compared between depressed and nondepressed persons. Methods: Nine Dutch cohorts were included, comprising 10,145 control subjects and 5283 persons with depression, established with diagnostic interviews or questionnaires. A proton nuclear magnetic resonance metabolomics platform provided 230 metabolite measures: 51 lipids, fatty acids, and low-molecular-weight metabolites; 98 lipid composition and particle concentration measures of lipoprotein subclasses; and 81 lipid and fatty acids ratios. For each metabolite measure, logistic regression analyses adjusted for gender, age, smoking, fasting status, and lipid-modifying medication were performed within cohort, followed by random-effects meta-analyses. Results: Of the 51 lipids, fatty acids, and low-molecular-weight metabolites, 21 were significantly related to depression (false discovery rate q <.05). Higher levels of apolipoprotein B, very-low-density lipoprotein cholesterol, triglycerides, diglycerides, total and monounsaturated fatty acids, fatty acid chain length, glycoprotein acetyls, tyrosine, and isoleucine and lower levels of high-density lipoprotein cholesterol, acetate, and apolipoprotein A1 were associated with increased odds of depression. Analyses of lipid composition indicators confirmed a shift toward less high-density lipoprotein and more very-low-density lipoprotein and triglyceride particles in depression. Associations appeared generally consistent across gender, age, and body mass index strata and across cohorts with depressive diagnoses versus symptoms. Conclusions: This large-scale meta-analysis indicates a clear distinctive profile of circulating lipid metabolites associated with depression, potentially opening new prevention or treatment avenues for depression and its associated cardiometabolic comorbidity.
AB - Background: Depression has been associated with metabolic alterations, which adversely impact cardiometabolic health. Here, a comprehensive set of metabolic markers, predominantly lipids, was compared between depressed and nondepressed persons. Methods: Nine Dutch cohorts were included, comprising 10,145 control subjects and 5283 persons with depression, established with diagnostic interviews or questionnaires. A proton nuclear magnetic resonance metabolomics platform provided 230 metabolite measures: 51 lipids, fatty acids, and low-molecular-weight metabolites; 98 lipid composition and particle concentration measures of lipoprotein subclasses; and 81 lipid and fatty acids ratios. For each metabolite measure, logistic regression analyses adjusted for gender, age, smoking, fasting status, and lipid-modifying medication were performed within cohort, followed by random-effects meta-analyses. Results: Of the 51 lipids, fatty acids, and low-molecular-weight metabolites, 21 were significantly related to depression (false discovery rate q <.05). Higher levels of apolipoprotein B, very-low-density lipoprotein cholesterol, triglycerides, diglycerides, total and monounsaturated fatty acids, fatty acid chain length, glycoprotein acetyls, tyrosine, and isoleucine and lower levels of high-density lipoprotein cholesterol, acetate, and apolipoprotein A1 were associated with increased odds of depression. Analyses of lipid composition indicators confirmed a shift toward less high-density lipoprotein and more very-low-density lipoprotein and triglyceride particles in depression. Associations appeared generally consistent across gender, age, and body mass index strata and across cohorts with depressive diagnoses versus symptoms. Conclusions: This large-scale meta-analysis indicates a clear distinctive profile of circulating lipid metabolites associated with depression, potentially opening new prevention or treatment avenues for depression and its associated cardiometabolic comorbidity.
KW - Biomarkers
KW - Cardiovascular
KW - Depression
KW - Metabolites
KW - Metabolomics
KW - Pooled analysis
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U2 - https://doi.org/10.1016/j.biopsych.2019.08.016
DO - https://doi.org/10.1016/j.biopsych.2019.08.016
M3 - Article
C2 - 31635762
SN - 0006-3223
VL - 87
SP - 409
EP - 418
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 5
ER -