Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy

M. Linnebank; S. Kemp; R. J. A. Wanders; W. J. Kleijer; M. L. T. van der Sterre; J. Gärtner; K. Fliessbach; A. Semmler; P. Sokolowski; W. Köhler; U. Schlegel; S. Schmidt; T. Klockgether; U. Wüllner

doi:https://doi.org/10.1212/01.wnl.0000196491.42058.6f

Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy

M. Linnebank, S. Kemp, R. J. A. Wanders, W. J. Kleijer, M. L. T. van der Sterre, J. Gärtner, K. Fliessbach, A. Semmler, P. Sokolowski, W. Köhler, U. Schlegel, S. Schmidt, T. Klockgether, U. Wüllner

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

A combined genotype of polymorphisms of methionine metabolism has been associated with CNS demyelination in methotrexate-treated patients. Within a sample of 86 patients with X-linked adrenoleukodystrophy, this genotype was overrepresented in a subgroup of 15 patients with adrenomyeloneuropathy (AMN) with CNS demyelination (adrenoleukomyeloneuropathy) in comparison to 49 AMN patients without CNS demyelination ("pure" AMN; p = 0.002), suggesting that methionine metabolism might contribute to the phenotypic variability in adrenoleukodystrophy

Original language	English
Pages (from-to)	442-443
Journal	Neurology
Volume	66
Issue number	3
DOIs	https://doi.org/10.1212/01.wnl.0000196491.42058.6f
Publication status	Published - 2006

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https://doi.org/10.1212/01.wnl.0000196491.42058.6f

Cite this

Linnebank, M., Kemp, S., Wanders, R. J. A., Kleijer, W. J., van der Sterre, M. L. T., Gärtner, J., Fliessbach, K., Semmler, A., Sokolowski, P., Köhler, W., Schlegel, U., Schmidt, S., Klockgether, T., & Wüllner, U. (2006). Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy. Neurology, 66(3), 442-443. https://doi.org/10.1212/01.wnl.0000196491.42058.6f

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title = "Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy",

abstract = "A combined genotype of polymorphisms of methionine metabolism has been associated with CNS demyelination in methotrexate-treated patients. Within a sample of 86 patients with X-linked adrenoleukodystrophy, this genotype was overrepresented in a subgroup of 15 patients with adrenomyeloneuropathy (AMN) with CNS demyelination (adrenoleukomyeloneuropathy) in comparison to 49 AMN patients without CNS demyelination ({"}pure{"} AMN; p = 0.002), suggesting that methionine metabolism might contribute to the phenotypic variability in adrenoleukodystrophy",

author = "M. Linnebank and S. Kemp and Wanders, {R. J. A.} and Kleijer, {W. J.} and {van der Sterre}, {M. L. T.} and J. G{\"a}rtner and K. Fliessbach and A. Semmler and P. Sokolowski and W. K{\"o}hler and U. Schlegel and S. Schmidt and T. Klockgether and U. W{\"u}llner",

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Linnebank, M, Kemp, S , Wanders, RJA, Kleijer, WJ, van der Sterre, MLT, Gärtner, J, Fliessbach, K, Semmler, A, Sokolowski, P, Köhler, W, Schlegel, U, Schmidt, S, Klockgether, T & Wüllner, U 2006, 'Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy', Neurology, vol. 66, no. 3, pp. 442-443. https://doi.org/10.1212/01.wnl.0000196491.42058.6f

TY - JOUR

T1 - Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy

AU - Linnebank, M.

AU - Kemp, S.

AU - Wanders, R. J. A.

AU - Kleijer, W. J.

AU - van der Sterre, M. L. T.

AU - Gärtner, J.

AU - Fliessbach, K.

AU - Semmler, A.

AU - Sokolowski, P.

AU - Köhler, W.

AU - Schlegel, U.

AU - Schmidt, S.

AU - Klockgether, T.

AU - Wüllner, U.

PY - 2006

Y1 - 2006

N2 - A combined genotype of polymorphisms of methionine metabolism has been associated with CNS demyelination in methotrexate-treated patients. Within a sample of 86 patients with X-linked adrenoleukodystrophy, this genotype was overrepresented in a subgroup of 15 patients with adrenomyeloneuropathy (AMN) with CNS demyelination (adrenoleukomyeloneuropathy) in comparison to 49 AMN patients without CNS demyelination ("pure" AMN; p = 0.002), suggesting that methionine metabolism might contribute to the phenotypic variability in adrenoleukodystrophy

AB - A combined genotype of polymorphisms of methionine metabolism has been associated with CNS demyelination in methotrexate-treated patients. Within a sample of 86 patients with X-linked adrenoleukodystrophy, this genotype was overrepresented in a subgroup of 15 patients with adrenomyeloneuropathy (AMN) with CNS demyelination (adrenoleukomyeloneuropathy) in comparison to 49 AMN patients without CNS demyelination ("pure" AMN; p = 0.002), suggesting that methionine metabolism might contribute to the phenotypic variability in adrenoleukodystrophy

U2 - https://doi.org/10.1212/01.wnl.0000196491.42058.6f

DO - https://doi.org/10.1212/01.wnl.0000196491.42058.6f

M3 - Article

C2 - 16476952

SN - 0028-3878

VL - 66

SP - 442

EP - 443

JO - Neurology

JF - Neurology

IS - 3

ER -