Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

B. Ribba; H. P. Grimm; B. Agoram; M. R. Davies; K. Gadkar; S. Niederer; N. van Riel; J. Timmis; P. H. van der Graaf

doi:https://doi.org/10.1002/psp4.12206

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

B. Ribba, H. P. Grimm, B. Agoram, M. R. Davies, K. Gadkar, S. Niederer, N. van Riel, J. Timmis, P. H. van der Graaf

Research output: Contribution to journal › Article › Academic › peer-review

26 Citations (Scopus)

Abstract

With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions

Original language	English
Pages (from-to)	496-498
Journal	CPT: pharmacometrics & systems pharmacology
Volume	6
Issue number	8
Early online date	2017
DOIs	https://doi.org/10.1002/psp4.12206
Publication status	Published - 2017

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https://doi.org/10.1002/psp4.12206

Cite this

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title = "Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation",

abstract = "With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions",

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AU - van Riel, N.

AU - Timmis, J.

AU - van der Graaf, P. H.

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