TY - JOUR
T1 - Methodology used in studies reporting chronic kidney disease prevalence: a systematic literature review
AU - Brück, Katharina
AU - Jager, Kitty J.
AU - Dounousi, Evangelia
AU - Kainz, Alexander
AU - Nitsch, Dorothea
AU - Ärnlöv, Johan
AU - Rothenbacher, Dietrich
AU - Browne, Gemma
AU - Capuano, Vincenzo
AU - Ferraro, Pietro Manuel
AU - Ferrieres, Jean
AU - Gambaro, Giovanni
AU - Guessous, Idris
AU - Hallan, Stein
AU - Kastarinen, Mika
AU - Navis, Gerjan
AU - Gonzalez, Alfonso Otero
AU - Palmieri, Luigi
AU - Romundstad, Solfrid
AU - Spoto, Belinda
AU - Stengel, Benedicte
AU - Tomson, Charles
AU - Tripepi, Giovanni
AU - Völzke, Henry
AU - Wiȩcek, Andrzej
AU - Gansevoort, Ron
AU - Schöttker, Ben
AU - Wanner, Christoph
AU - Vinhas, Jose
AU - Zoccali, Carmine
AU - van Biesen, Wim
AU - Stel, Vianda S.
AU - AUTHOR GROUP
AU - Jousilahti, Pekka
AU - Helmer, Catherine
AU - Metzger, Marie
AU - Ruidavets, Jean Bernard
AU - Bongard, Vanina
AU - Koenig, Wolfgang
AU - Denkinger, Michael D.
AU - Brenner, Hermann
AU - Saum, Kai-Uwe
AU - Nauck, Matthias
AU - Stracke, Sylvia
AU - Perry, Ivan
AU - Eustace, Joseph
AU - Lupo, Antonio
AU - Donfrancesco, Chiara
AU - Palleschi, Simonetta
AU - Lamaida, Norman
AU - Capuano, Ernesto
PY - 2015
Y1 - 2015
N2 - Many publications report the prevalence of chronic kidney disease (CKD) in the general population. Comparisons across studies are hampered as CKD prevalence estimations are influenced by study population characteristics and laboratory methods. For this systematic review, two researchers independently searched PubMed, MEDLINE and EMBASE to identify all original research articles that were published between 1 January 2003 and 1 November 2014 reporting the prevalence of CKD in the European adult general population. Data on study methodology and reporting of CKD prevalence results were independently extracted by two researchers. We identified 82 eligible publications and included 48 publications of individual studies for the data extraction. There was considerable variation in population sample selection. The majority of studies did not report the sampling frame used, and the response ranged from 10 to 87%. With regard to the assessment of kidney function, 67% used a Jaffe assay, whereas 13% used the enzymatic assay for creatinine determination. Isotope dilution mass spectrometry calibration was used in 29%. The CKD-EPI (52%) and MDRD (75%) equations were most often used to estimate glomerular filtration rate (GFR). CKD was defined as estimated GFR (eGFR) <60 mL/min/1.73 m(2) in 92% of studies. Urinary markers of CKD were assessed in 60% of the studies. CKD prevalence was reported by sex and age strata in 54 and 50% of the studies, respectively. In publications with a primary objective of reporting CKD prevalence, 39% reported a 95% confidence interval. The findings from this systematic review showed considerable variation in methods for sampling the general population and assessment of kidney function across studies reporting CKD prevalence. These results are utilized to provide recommendations to help optimize both the design and the reporting of future CKD prevalence studies, which will enhance comparability of study results
AB - Many publications report the prevalence of chronic kidney disease (CKD) in the general population. Comparisons across studies are hampered as CKD prevalence estimations are influenced by study population characteristics and laboratory methods. For this systematic review, two researchers independently searched PubMed, MEDLINE and EMBASE to identify all original research articles that were published between 1 January 2003 and 1 November 2014 reporting the prevalence of CKD in the European adult general population. Data on study methodology and reporting of CKD prevalence results were independently extracted by two researchers. We identified 82 eligible publications and included 48 publications of individual studies for the data extraction. There was considerable variation in population sample selection. The majority of studies did not report the sampling frame used, and the response ranged from 10 to 87%. With regard to the assessment of kidney function, 67% used a Jaffe assay, whereas 13% used the enzymatic assay for creatinine determination. Isotope dilution mass spectrometry calibration was used in 29%. The CKD-EPI (52%) and MDRD (75%) equations were most often used to estimate glomerular filtration rate (GFR). CKD was defined as estimated GFR (eGFR) <60 mL/min/1.73 m(2) in 92% of studies. Urinary markers of CKD were assessed in 60% of the studies. CKD prevalence was reported by sex and age strata in 54 and 50% of the studies, respectively. In publications with a primary objective of reporting CKD prevalence, 39% reported a 95% confidence interval. The findings from this systematic review showed considerable variation in methods for sampling the general population and assessment of kidney function across studies reporting CKD prevalence. These results are utilized to provide recommendations to help optimize both the design and the reporting of future CKD prevalence studies, which will enhance comparability of study results
U2 - https://doi.org/10.1093/ndt/gfv131
DO - https://doi.org/10.1093/ndt/gfv131
M3 - Review article
C2 - 26209739
SN - 0931-0509
VL - 30
SP - iv6-i16
JO - Nephrology, dialysis, transplantation
JF - Nephrology, dialysis, transplantation
IS - Suppl. 4
ER -