Microglia, amyloid and dementia in Alzheimer disease. A correlative study.

Y.M. Arends; C. Duyckaerts; J.M. Rozemuller; P. Eikelenboom; J.J. Hauw

doi:https://doi.org/10.1016/S0197-4580(00)00094-4

Microglia, amyloid and dementia in Alzheimer disease. A correlative study.

Y.M. Arends, C. Duyckaerts, J.M. Rozemuller, P. Eikelenboom, J.J. Hauw

Research output: Contribution to journal › Article › Academic › peer-review

128 Citations (Scopus)

Abstract

To elucidate the role of microglia in Alzheimer's disease, a clinicopathological study was performed involving 26 cases, the mental status of which had been studied pre mortem by the Blessed test score (BTS). We measured the volume density of CD 68 immunoreactive (IR) microglia, congophilic plaques and Abeta deposits, and the numerical density of neurofibrillary tangles (NFT) in a sample of Area 9 (middle frontal gyrus). Dementia was significantly correlated only with the volume density of Abeta deposits and the numerical density of NFT. The volume densities of microglia and congophilic plaques were strongly correlated. With the intellectual status used as a time scale, IR microglia and amyloid deposits appeared almost simultaneously at an early stage in the pathological cascade and decreased, whereas Abeta and NFT were still accumulating. The intellectual deficit seemed to be more significantly related to the latter two lesions than to the microglia-amyloid complex, that was visible at an earlier stage (around BTS = 15)

Original language	English
Pages (from-to)	39-47
Journal	Neurobiology of aging
Volume	21
Issue number	1
DOIs	https://doi.org/10.1016/S0197-4580(00)00094-4
Publication status	Published - 2000

Access to Document

https://doi.org/10.1016/S0197-4580(00)00094-4

Cite this

@article{018f2db10a4543c389ec1e9df153a6da,

title = "Microglia, amyloid and dementia in Alzheimer disease. A correlative study.",

abstract = "To elucidate the role of microglia in Alzheimer's disease, a clinicopathological study was performed involving 26 cases, the mental status of which had been studied pre mortem by the Blessed test score (BTS). We measured the volume density of CD 68 immunoreactive (IR) microglia, congophilic plaques and Abeta deposits, and the numerical density of neurofibrillary tangles (NFT) in a sample of Area 9 (middle frontal gyrus). Dementia was significantly correlated only with the volume density of Abeta deposits and the numerical density of NFT. The volume densities of microglia and congophilic plaques were strongly correlated. With the intellectual status used as a time scale, IR microglia and amyloid deposits appeared almost simultaneously at an early stage in the pathological cascade and decreased, whereas Abeta and NFT were still accumulating. The intellectual deficit seemed to be more significantly related to the latter two lesions than to the microglia-amyloid complex, that was visible at an earlier stage (around BTS = 15)",

author = "Y.M. Arends and C. Duyckaerts and J.M. Rozemuller and P. Eikelenboom and J.J. Hauw",

year = "2000",

doi = "https://doi.org/10.1016/S0197-4580(00)00094-4",

language = "English",

volume = "21",

pages = "39--47",

journal = "Neurobiology of aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Microglia, amyloid and dementia in Alzheimer disease. A correlative study.

AU - Arends, Y.M.

AU - Duyckaerts, C.

AU - Rozemuller, J.M.

AU - Eikelenboom, P.

AU - Hauw, J.J.

PY - 2000

Y1 - 2000

N2 - To elucidate the role of microglia in Alzheimer's disease, a clinicopathological study was performed involving 26 cases, the mental status of which had been studied pre mortem by the Blessed test score (BTS). We measured the volume density of CD 68 immunoreactive (IR) microglia, congophilic plaques and Abeta deposits, and the numerical density of neurofibrillary tangles (NFT) in a sample of Area 9 (middle frontal gyrus). Dementia was significantly correlated only with the volume density of Abeta deposits and the numerical density of NFT. The volume densities of microglia and congophilic plaques were strongly correlated. With the intellectual status used as a time scale, IR microglia and amyloid deposits appeared almost simultaneously at an early stage in the pathological cascade and decreased, whereas Abeta and NFT were still accumulating. The intellectual deficit seemed to be more significantly related to the latter two lesions than to the microglia-amyloid complex, that was visible at an earlier stage (around BTS = 15)

AB - To elucidate the role of microglia in Alzheimer's disease, a clinicopathological study was performed involving 26 cases, the mental status of which had been studied pre mortem by the Blessed test score (BTS). We measured the volume density of CD 68 immunoreactive (IR) microglia, congophilic plaques and Abeta deposits, and the numerical density of neurofibrillary tangles (NFT) in a sample of Area 9 (middle frontal gyrus). Dementia was significantly correlated only with the volume density of Abeta deposits and the numerical density of NFT. The volume densities of microglia and congophilic plaques were strongly correlated. With the intellectual status used as a time scale, IR microglia and amyloid deposits appeared almost simultaneously at an early stage in the pathological cascade and decreased, whereas Abeta and NFT were still accumulating. The intellectual deficit seemed to be more significantly related to the latter two lesions than to the microglia-amyloid complex, that was visible at an earlier stage (around BTS = 15)

U2 - https://doi.org/10.1016/S0197-4580(00)00094-4

DO - https://doi.org/10.1016/S0197-4580(00)00094-4

M3 - Article

C2 - 10794847

SN - 0197-4580

VL - 21

SP - 39

EP - 47

JO - Neurobiology of aging

JF - Neurobiology of aging

IS - 1

ER -