TY - JOUR
T1 - Microparticles and exosomes: impact on normal and complicated pregnancy
AU - Toth, Bettina
AU - Lok, Christianne A. R.
AU - Böing, Anita
AU - Diamant, Michaela
AU - van der Post, Joris A. M.
AU - Friese, Klaus
AU - Nieuwland, Rienk
PY - 2007
Y1 - 2007
N2 - Eukaryotic cells release vesicles into their environment by membrane shedding (ectosomes or microparticles) and secretion (exosomes). Microparticles and exosomes occur commonly in vitro and in vivo. The occurrence, composition and function(s) of these vesicles change during disease (progression). During the last decade, the scientific and clinical interest increased tremendously. Evidence is accumulating that microparticles and exosomes may be of pathophysiological relevance in autoimmune, cardiovascular and thromboembolic diseases, as well as inflammatory and infectious disorders. In this review, we will summarize the discovery, biology, structure and function of microparticles and exosomes, and discuss their (patho-) physiological role during normal and complicated pregnancy
AB - Eukaryotic cells release vesicles into their environment by membrane shedding (ectosomes or microparticles) and secretion (exosomes). Microparticles and exosomes occur commonly in vitro and in vivo. The occurrence, composition and function(s) of these vesicles change during disease (progression). During the last decade, the scientific and clinical interest increased tremendously. Evidence is accumulating that microparticles and exosomes may be of pathophysiological relevance in autoimmune, cardiovascular and thromboembolic diseases, as well as inflammatory and infectious disorders. In this review, we will summarize the discovery, biology, structure and function of microparticles and exosomes, and discuss their (patho-) physiological role during normal and complicated pregnancy
U2 - https://doi.org/10.1111/j.1600-0897.2007.00532.x
DO - https://doi.org/10.1111/j.1600-0897.2007.00532.x
M3 - Review article
C2 - 17922691
SN - 1046-7408
VL - 58
SP - 389
EP - 402
JO - American journal of reproductive immunology (New York, N.Y.
JF - American journal of reproductive immunology (New York, N.Y.
IS - 5
ER -