TY - JOUR
T1 - Microparticles and Exosomes in Gynecologic Neoplasias
AU - Nieuwland, Rienk
AU - van der Post, Joris A. M.
AU - Lok Gemma, Christianne A. R.
AU - Kenter, G.
AU - Sturk, Augueste
PY - 2010
Y1 - 2010
N2 - This review presents an overview of the functions of microparticles and exosomes in gynecologic neoplasias. Growing evidence suggests that vesicles released from cancer cells in gynecologic malignancies contribute to the hypercoagulable state of these patients and contribute to tumor progression by suppressing the immune system, facilitating extracellular matrix degradation and removal of cytostatics from the tumor cell. Exosomes from ovarian carcinoma cells were shown to be present in peripheral blood and to augment tumor growth, suggesting that these vesicles directly support growth of tumor cells
AB - This review presents an overview of the functions of microparticles and exosomes in gynecologic neoplasias. Growing evidence suggests that vesicles released from cancer cells in gynecologic malignancies contribute to the hypercoagulable state of these patients and contribute to tumor progression by suppressing the immune system, facilitating extracellular matrix degradation and removal of cytostatics from the tumor cell. Exosomes from ovarian carcinoma cells were shown to be present in peripheral blood and to augment tumor growth, suggesting that these vesicles directly support growth of tumor cells
U2 - https://doi.org/10.1055/s-0030-1267046
DO - https://doi.org/10.1055/s-0030-1267046
M3 - Article
C2 - 21049392
SN - 0094-6176
VL - 36
SP - 925
EP - 929
JO - Seminars in Thrombosis and Hemostasis
JF - Seminars in Thrombosis and Hemostasis
IS - 8
ER -