TY - JOUR
T1 - Microvascular dysfunction
T2 - Causative role in the association between hypertension, insulin resistance and the metabolic syndrome?
AU - Serné, Erik H.
AU - DeJongh, Renate T.
AU - Eringa, Etto C.
AU - Ijzerman, Richard G.
AU - DeBoer, Michiel P.
AU - Stehouwer, Coen D.A.
PY - 2006/12/1
Y1 - 2006/12/1
N2 - The metabolic syndrome defines a clustering of metabolic risk factors that confers an increased risk for type 2 diabetes and cardiovascular disease. The metabolic syndrome seems to have multiple etiological factors and microvascular dysfunction may be one potential factor explaining the clustering of multiple metabolic risk factors including hypertension, obesity, insulin resistance and glucose intolerance. Microvascular dysfunction may increase not only peripheral vascular resistance and blood pressure, but may also decrease insulin-mediated glucose uptake in muscle. The present article summarizes some of the data concerning the role of microvascular dysfunction in the metabolic syndrome.
AB - The metabolic syndrome defines a clustering of metabolic risk factors that confers an increased risk for type 2 diabetes and cardiovascular disease. The metabolic syndrome seems to have multiple etiological factors and microvascular dysfunction may be one potential factor explaining the clustering of multiple metabolic risk factors including hypertension, obesity, insulin resistance and glucose intolerance. Microvascular dysfunction may increase not only peripheral vascular resistance and blood pressure, but may also decrease insulin-mediated glucose uptake in muscle. The present article summarizes some of the data concerning the role of microvascular dysfunction in the metabolic syndrome.
UR - http://www.scopus.com/inward/record.url?scp=39049183894&partnerID=8YFLogxK
U2 - https://doi.org/10.1042/bse0420163
DO - https://doi.org/10.1042/bse0420163
M3 - Article
C2 - 17144887
SN - 0071-1365
VL - 42
SP - 163
EP - 176
JO - Essays in biochemistry
JF - Essays in biochemistry
ER -