TY - JOUR
T1 - Mild chronic kidney disease is associated with cognitive function in patients presenting at a memory clinic
AU - Romijn, Marloes D.M.
AU - Van Marum, Rob J.
AU - Emmelot-Vonk, Mariëlle H.
AU - Verhaar, Harald J.J.
AU - Koek, Huiberdina L.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Objective In dialysis-dependent and severe chronic kidney disease (CKD) patients, cognitive impairment is found in 16-29%. In community-dwelling population without dementia mixed results have been observed. We investigated the relationship between renal function and cognition in patients from a memory clinic. Methods We performed a cross-sectional study of consecutive patients from a memory clinic between 2005 and 2009. Renal function was estimated with the Modification of Diet in Renal Diseases (MDRD) and Cockcroft-Gault (CG) formulas, and categorized into ordinal groups: reference ≥60-ml/min/1.73-m2, mild CKD 45-59-ml/min/1.73-m2 and moderate CKD <45-ml/min/1.73-m2. Cognitive function was dichotomized (Mini-Mental State Examination (MMSE) ≥24 vs. <24). We performed multiple logistic regression analyses with adjustment for potential confounders. Results The cohort comprised 581 patients (mean age 77-±-10-years). With the MDRD, there were 74 (12%) cases with moderate CKD and 108 (18%) with mild CKD. With the CG, these prevalences were 144 (30%) and 130 (27%). In mild CKD patients, a significant relationship was found between cognitive function and CKD according to the MDRD-formula [adjusted OR 2.10; 95%CI 1.09-4.05]. In moderate CKD patients, no significant adjusted associations were found. In patients without dementia, significant adjusted associations were found between CKD and MMSE (MDRD: mild CKD [OR 5.09; 95%CI 1.17-22.14] and moderate CKD [OR 5.03; 95%CI 1.10-22.98]; CG: mild CKD [OR 6.16; 95%CI 1.17-32.50] and moderate CKD [OR 5.60; 95%CI 1.01-30.91]). Conclusion This study showed a significant association between mild CKD and impaired cognitive function in patients from a memory clinic, especially in patients without dementia.
AB - Objective In dialysis-dependent and severe chronic kidney disease (CKD) patients, cognitive impairment is found in 16-29%. In community-dwelling population without dementia mixed results have been observed. We investigated the relationship between renal function and cognition in patients from a memory clinic. Methods We performed a cross-sectional study of consecutive patients from a memory clinic between 2005 and 2009. Renal function was estimated with the Modification of Diet in Renal Diseases (MDRD) and Cockcroft-Gault (CG) formulas, and categorized into ordinal groups: reference ≥60-ml/min/1.73-m2, mild CKD 45-59-ml/min/1.73-m2 and moderate CKD <45-ml/min/1.73-m2. Cognitive function was dichotomized (Mini-Mental State Examination (MMSE) ≥24 vs. <24). We performed multiple logistic regression analyses with adjustment for potential confounders. Results The cohort comprised 581 patients (mean age 77-±-10-years). With the MDRD, there were 74 (12%) cases with moderate CKD and 108 (18%) with mild CKD. With the CG, these prevalences were 144 (30%) and 130 (27%). In mild CKD patients, a significant relationship was found between cognitive function and CKD according to the MDRD-formula [adjusted OR 2.10; 95%CI 1.09-4.05]. In moderate CKD patients, no significant adjusted associations were found. In patients without dementia, significant adjusted associations were found between CKD and MMSE (MDRD: mild CKD [OR 5.09; 95%CI 1.17-22.14] and moderate CKD [OR 5.03; 95%CI 1.10-22.98]; CG: mild CKD [OR 6.16; 95%CI 1.17-32.50] and moderate CKD [OR 5.60; 95%CI 1.01-30.91]). Conclusion This study showed a significant association between mild CKD and impaired cognitive function in patients from a memory clinic, especially in patients without dementia.
KW - chronic kidney disease
KW - cognition
KW - dementia
KW - memory clinic
UR - http://www.scopus.com/inward/record.url?scp=84930729594&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/gps.4226
DO - https://doi.org/10.1002/gps.4226
M3 - Article
C2 - 25366465
SN - 0885-6230
VL - 30
SP - 758
EP - 765
JO - International journal of geriatric psychiatry
JF - International journal of geriatric psychiatry
IS - 7
ER -