TY - JOUR
T1 - Mild renal dysfunction is associated with electrocardiographic left ventricular hypertrophy
AU - Smilde, Tom D. J.
AU - Asselbergs, Folkert W.
AU - Hillege, Hans L.
AU - Voors, Adriaan A.
AU - Kors, Jan A.
AU - Gansevoort, Ron T.
AU - van Gilst, Wiek H.
AU - de Jong, Paul E.
AU - van Veldhuisen, Dirk J.
PY - 2005
Y1 - 2005
N2 - Background: Both renal dysfunction and left ventricular hypertrophy (LVH) are signs of end-organ damage, risk markers of cardiovascular (CV) disease and chronic heart failure. In selected populations such as those with diabetes or hypertension, renal dysfunction was found to be related to LVH. We studied the relation between renal dysfunction and LVH in a cross-sectional study in 8592 inhabitants from Groningen, The Netherlands. Methods: Standard 12-lead electrocardiograms were recorded, and LVH was classified using the Cornell voltage duration product. Renal dysfunction was defined as creatinine clearance <60 mL/min/1.73 m2 or microalbuminuria (30 to 300 mg/24 h). Results: Electrocardiographic signs of LVH were present in 396 of subjects (5.3%). Subjects with LVH were older and had a more extensive CV risk profile. We found that LVH was more prevalent in subjects with renal dysfunction than in those without (8% v 4%, P < .001). Multivariate regression analysis demonstrated that renal dysfunction was independently related to a 1.47-fold increased risk of the presence of LVH (95% CI = 1.15 to 1.88, P =. 009). In addition, both creatinine clearance (OR = 1.56, 95% CI = 1.07 to 2.2, P =. 044) and microalbuminuria (OR = 1.37, 95% CI = 1.04 to 1.80, P =. 024) were independently associated with the presence of LVH. Conclusion: Subjects with mild renal dysfunction have a substantially higher risk of LVH on electrocardiography than those without renal dysfunction. © 2005 American Journal of Hypertension, Ltd.
AB - Background: Both renal dysfunction and left ventricular hypertrophy (LVH) are signs of end-organ damage, risk markers of cardiovascular (CV) disease and chronic heart failure. In selected populations such as those with diabetes or hypertension, renal dysfunction was found to be related to LVH. We studied the relation between renal dysfunction and LVH in a cross-sectional study in 8592 inhabitants from Groningen, The Netherlands. Methods: Standard 12-lead electrocardiograms were recorded, and LVH was classified using the Cornell voltage duration product. Renal dysfunction was defined as creatinine clearance <60 mL/min/1.73 m2 or microalbuminuria (30 to 300 mg/24 h). Results: Electrocardiographic signs of LVH were present in 396 of subjects (5.3%). Subjects with LVH were older and had a more extensive CV risk profile. We found that LVH was more prevalent in subjects with renal dysfunction than in those without (8% v 4%, P < .001). Multivariate regression analysis demonstrated that renal dysfunction was independently related to a 1.47-fold increased risk of the presence of LVH (95% CI = 1.15 to 1.88, P =. 009). In addition, both creatinine clearance (OR = 1.56, 95% CI = 1.07 to 2.2, P =. 044) and microalbuminuria (OR = 1.37, 95% CI = 1.04 to 1.80, P =. 024) were independently associated with the presence of LVH. Conclusion: Subjects with mild renal dysfunction have a substantially higher risk of LVH on electrocardiography than those without renal dysfunction. © 2005 American Journal of Hypertension, Ltd.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=15744395854&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/15797651
U2 - https://doi.org/10.1016/j.amjhyper.2004.09.015
DO - https://doi.org/10.1016/j.amjhyper.2004.09.015
M3 - Article
C2 - 15797651
SN - 0895-7061
VL - 18
SP - 342
EP - 347
JO - American journal of hypertension
JF - American journal of hypertension
IS - 3
ER -