TY - JOUR
T1 - Misinterpretation of the mouse ECG: 'musing the waves of Mus musculus'
AU - Boukens, Bastiaan J.
AU - Rivaud, Mathilde R.
AU - Rentschler, Stacey
AU - Coronel, Ruben
PY - 2014
Y1 - 2014
N2 - The ECG is a primary diagnostic tool in patients suffering from heart disease, underscoring the importance of understanding factors contributing to normal and abnormal electrical patterns. Over the past few decades, transgenic mouse models have been increasingly used to study pathophysiological mechanisms of human heart diseases. In order to allow extrapolation of insights gained from murine models to the human condition, knowledge of the similarities and differences between the mouse and human ECG is of crucial importance. In this review, we briefly discuss the physiological mechanisms underlying differences between the baseline ECG of humans and mice, and provide a framework for understanding how these inherent differences are relevant to the interpretation of the mouse ECG during pathology and to the translation of the results from the mouse to man
AB - The ECG is a primary diagnostic tool in patients suffering from heart disease, underscoring the importance of understanding factors contributing to normal and abnormal electrical patterns. Over the past few decades, transgenic mouse models have been increasingly used to study pathophysiological mechanisms of human heart diseases. In order to allow extrapolation of insights gained from murine models to the human condition, knowledge of the similarities and differences between the mouse and human ECG is of crucial importance. In this review, we briefly discuss the physiological mechanisms underlying differences between the baseline ECG of humans and mice, and provide a framework for understanding how these inherent differences are relevant to the interpretation of the mouse ECG during pathology and to the translation of the results from the mouse to man
U2 - https://doi.org/10.1113/jphysiol.2014.279380
DO - https://doi.org/10.1113/jphysiol.2014.279380
M3 - Review article
C2 - 25260630
SN - 0022-3751
VL - 592
SP - 4613
EP - 4626
JO - Journal of physiology
JF - Journal of physiology
IS - Part 21
ER -