Mitochondrial Ca2+-Handling in Fast Skeletal Muscle Fibers from Wild Type and Calsequestrin-Null Mice

M. Scorzeto, M. Giacomello, L. Toniolo, M. Canato, B. Blaauw, C. Paolini, F. Protasi, C. Reggiani, G.J.M. Stienen

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Abstract

Mitochondrial calcium handling and its relation with calcium released from sarcoplasmic reticulum (SR) in muscle tissue are subject of lively debate. In this study we aimed to clarify how the SR determines mitochondrial calcium handling using dCASQ-null mice which lack both isoforms of the major Ca
Original languageEnglish
Article numbere74919
JournalPLOS ONE
Volume8
Issue number10
DOIs
Publication statusPublished - 2013

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