TY - JOUR
T1 - Modeling endometrial cancer: Past, present, and future
AU - Nyen, Tom Van
AU - Moiola, Cristian P.
AU - Colas, Eva
AU - Annibali, Daniela
AU - Amant, Frédéric
PY - 2018
Y1 - 2018
N2 - Endometrial cancer is the most common type of cancer of the female reproductive tract. Although prognosis is generally good for patients with low-grade and early-stage diseases, the outcomes for high-grade and metastatic/recurrent cases remain poor, since traditional chemotherapy regimens based on platinum and taxanes have limited effects. No targeted agents have been approved so far, although several new drugs have been tested without striking results in clinical trials. Over the last decades, many efforts have been made towards the establishment and development of preclinical models, aiming at recapitulating the structural and molecular determinants of the disease. Here, we present an overview of the most commonly used in vitro and in vivo models and discuss their peculiar features, describing their main applications and the value in the advancement of both fundamental and translational endometrial cancer research.
AB - Endometrial cancer is the most common type of cancer of the female reproductive tract. Although prognosis is generally good for patients with low-grade and early-stage diseases, the outcomes for high-grade and metastatic/recurrent cases remain poor, since traditional chemotherapy regimens based on platinum and taxanes have limited effects. No targeted agents have been approved so far, although several new drugs have been tested without striking results in clinical trials. Over the last decades, many efforts have been made towards the establishment and development of preclinical models, aiming at recapitulating the structural and molecular determinants of the disease. Here, we present an overview of the most commonly used in vitro and in vivo models and discuss their peculiar features, describing their main applications and the value in the advancement of both fundamental and translational endometrial cancer research.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85052093782&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30096949
U2 - https://doi.org/10.3390/ijms19082348
DO - https://doi.org/10.3390/ijms19082348
M3 - Review article
C2 - 30096949
SN - 1661-6596
VL - 19
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 8
M1 - 2348
ER -