Modelling of multiple sclerosis: lessons learned in a non-human primate

Bert A 't Hart; Jon D Laman; Jan Bauer; Erwin Blezer; Yvette van Kooyk; Rogier Q Hintzen

doi:https://doi.org/10.1016/S1474-4422(04)00879-8

Modelling of multiple sclerosis: lessons learned in a non-human primate

Bert A 't Hart, Jon D Laman, Jan Bauer, Erwin Blezer, Yvette van Kooyk, Rogier Q Hintzen

Molecular cell biology and Immunology (VUmc)

Research output: Contribution to journal › Review article › Academic › peer-review

84 Citations (Scopus)

Abstract

The many, highly specific, biological therapies for immune-based diseases create a need for valid preclinical animal models. The wide immunological gap between human beings and laboratory mouse or rat models makes many disease models in these species invalid. In this review, we report a non-human-primate model of chronic multiple sclerosis (MS)-experimental autoimmune encephalitis (EAE) in the common marmoset (Callithrix jacchus)-that can help bridge this wide gap. The genetic and immunological similarity of marmosets and human beings and the clinical and neuropathological similarity of the EAE model to MS provide a unique experimental platform for research into basic immunopathogenetic mechanisms and for the development of more effective treatments for MS.

Original language	English
Pages (from-to)	588-97
Number of pages	10
Journal	Lancet neurology
Volume	3
Issue number	10
DOIs	https://doi.org/10.1016/S1474-4422(04)00879-8
Publication status	Published - Oct 2004

Keywords

Animals
Callithrix
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental/genetics
Humans
Multiple Sclerosis/genetics

Access to Document

https://doi.org/10.1016/S1474-4422(04)00879-8

Cite this

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title = "Modelling of multiple sclerosis: lessons learned in a non-human primate",

abstract = "The many, highly specific, biological therapies for immune-based diseases create a need for valid preclinical animal models. The wide immunological gap between human beings and laboratory mouse or rat models makes many disease models in these species invalid. In this review, we report a non-human-primate model of chronic multiple sclerosis (MS)-experimental autoimmune encephalitis (EAE) in the common marmoset (Callithrix jacchus)-that can help bridge this wide gap. The genetic and immunological similarity of marmosets and human beings and the clinical and neuropathological similarity of the EAE model to MS provide a unique experimental platform for research into basic immunopathogenetic mechanisms and for the development of more effective treatments for MS.",

keywords = "Animals, Callithrix, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental/genetics, Humans, Multiple Sclerosis/genetics",

author = "{'t Hart}, {Bert A} and Laman, {Jon D} and Jan Bauer and Erwin Blezer and {van Kooyk}, Yvette and Hintzen, {Rogier Q}",

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T1 - Modelling of multiple sclerosis

T2 - lessons learned in a non-human primate

AU - 't Hart, Bert A

AU - Laman, Jon D

AU - Bauer, Jan

AU - Blezer, Erwin

AU - van Kooyk, Yvette

AU - Hintzen, Rogier Q

PY - 2004/10

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N2 - The many, highly specific, biological therapies for immune-based diseases create a need for valid preclinical animal models. The wide immunological gap between human beings and laboratory mouse or rat models makes many disease models in these species invalid. In this review, we report a non-human-primate model of chronic multiple sclerosis (MS)-experimental autoimmune encephalitis (EAE) in the common marmoset (Callithrix jacchus)-that can help bridge this wide gap. The genetic and immunological similarity of marmosets and human beings and the clinical and neuropathological similarity of the EAE model to MS provide a unique experimental platform for research into basic immunopathogenetic mechanisms and for the development of more effective treatments for MS.

AB - The many, highly specific, biological therapies for immune-based diseases create a need for valid preclinical animal models. The wide immunological gap between human beings and laboratory mouse or rat models makes many disease models in these species invalid. In this review, we report a non-human-primate model of chronic multiple sclerosis (MS)-experimental autoimmune encephalitis (EAE) in the common marmoset (Callithrix jacchus)-that can help bridge this wide gap. The genetic and immunological similarity of marmosets and human beings and the clinical and neuropathological similarity of the EAE model to MS provide a unique experimental platform for research into basic immunopathogenetic mechanisms and for the development of more effective treatments for MS.

KW - Animals

KW - Callithrix

KW - Disease Models, Animal

KW - Encephalomyelitis, Autoimmune, Experimental/genetics

KW - Humans

KW - Multiple Sclerosis/genetics

U2 - https://doi.org/10.1016/S1474-4422(04)00879-8

DO - https://doi.org/10.1016/S1474-4422(04)00879-8

M3 - Review article

C2 - 15380155

SN - 1474-4422

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JO - Lancet neurology

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