Abstract
Wavelength discrimination in goldfish was measured behaviourally. Both acute application of ethambutol injected into the eye and chronic application by feeding the animals daily 25 mg ethambutol for 1 month had the same effect on wavelength discrimination in the range of 560-640 nm. This means that: (1) electrophysiological experiments, in which drug application is primarily acute, reflect the same disturbance as behavioural experiments, in which drug application is chronic; and that (2) the origin of the color vision defect must be retinal. Furthermore reduction in stimulus intensity by 2 log units caused, in control fish, a similar disturbance in wavelength discrimination as induced by ethambutol, whereas an increase of stimulus intensity by 2 log units abolished in ethambutol-fed fish the discrimination disturbance. These results indicate that ethambutol shifts the threshold for wavelength discrimination without changing the absolute sensitivity of the cone systems
Original language | English |
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Pages (from-to) | 3519-3525 |
Journal | Vision research |
Volume | 36 |
Issue number | 21 |
DOIs | |
Publication status | Published - 1996 |