TY - JOUR
T1 - Monobenzone-induced depigmentation: from enzymatic blockade to autoimmunity
AU - van den Boorn, Jasper G.
AU - Melief, Cornelis J.
AU - Luiten, Rosalie M.
PY - 2011
Y1 - 2011
N2 - Autoimmune side-effects such as vitiligo regularly occur during melanoma immunotherapy. As vitiligo development is associated with a superior prognosis, the active induction of vitiligo in melanoma patients can be a useful tactic. The potent skin-depigmenting agent monobenzone can be used successfully for this purpose. However, until recently, the mechanism of action behind monobenzone-induced skin depigmentation was unclear. Lately, the mechanistic basis for the augmented immunogenicity of monobenzone-exposed pigmented cells has been unveiled, and their active role in the induction of autoimmune T-cell-mediated vitiligo has become apparent. Here, we provide an immunological framework in which we condense this knowledge to an integrated theory of the generation of monobenzone-induced vitiligo
AB - Autoimmune side-effects such as vitiligo regularly occur during melanoma immunotherapy. As vitiligo development is associated with a superior prognosis, the active induction of vitiligo in melanoma patients can be a useful tactic. The potent skin-depigmenting agent monobenzone can be used successfully for this purpose. However, until recently, the mechanism of action behind monobenzone-induced skin depigmentation was unclear. Lately, the mechanistic basis for the augmented immunogenicity of monobenzone-exposed pigmented cells has been unveiled, and their active role in the induction of autoimmune T-cell-mediated vitiligo has become apparent. Here, we provide an immunological framework in which we condense this knowledge to an integrated theory of the generation of monobenzone-induced vitiligo
U2 - https://doi.org/10.1111/j.1755-148X.2011.00878.x
DO - https://doi.org/10.1111/j.1755-148X.2011.00878.x
M3 - Article
C2 - 21689385
SN - 1755-1471
VL - 24
SP - 673
EP - 679
JO - Pigment cell & melanoma research
JF - Pigment cell & melanoma research
IS - 4
ER -